A83586C, a new depsipeptide antibiotic.
作者信息
Smitka T A, Deeter J B, Hunt A H, Mertz F P, Ellis R M, Boeck L D, Yao R C
机构信息
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
出版信息
J Antibiot (Tokyo). 1988 Jun;41(6):726-33. doi: 10.7164/antibiotics.41.726.
PMID:3403366
Abstract
A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.
摘要
Zotero 插件