Northwestern Medicine, Evanston, IL, United States of America.
Home Centered Care Institute, Schaumburg, IL, United States of America.
PLoS One. 2021 May 25;16(5):e0252151. doi: 10.1371/journal.pone.0252151. eCollection 2021.
Comprehensive medication review is a patient-centered approach to optimize medication use and improve patient outcomes. This study outlines a pilot model of care in which a remote corporate-based clinical pharmacist implemented comprehensive medication reviews for a cohort of medically complex home-based primary care (HBPC) patients.
Ninety-six medically complex patients were assessed for medication-related problems. Data collected on these patients were: number of chronic conditions, number of medications, appropriate indication for each medication, dose appropriateness, drug interactions, recommendations for medication optimization and deprescribing. The number of accepted recommendations by the HBPC practice was analyzed.
On average, the patients were 82 years old and had 13 chronic conditions. They were taking a median of 17 medications. Over a four-month pilot period, 175 medication recommendations were made, and 53 (30.3%) of them were accepted, with most common being medication discontinuation, deprescribing, and dose adjustments. Sixty-four (66.7%) patients were on a medication listed as potentially inappropriate for use in older adults. The most common potentially inappropriate medication was a proton-pump inhibitor (38.5%), followed by aspirin (24%), tramadol (15.6%), a benzodiazepine (13.5%) or an opioid (8.3%). Eighty-one medications were recommended for deprescribing and 27 medications were discontinued (33.3%). There were 24 recommended dose adjustments and 11 medications were dose adjusted (45.8%). Thirty-four medications were suggested as an addition to the current patient regimen, 2 medications were added (5.9%).
Pharmacist comprehensive medication review is a necessary component of the HBPC healthcare continuum. Additional research is needed to examine whether aligning pharmacists to deliver support to HBPC improves clinical outcomes, reduces healthcare expenditures and improves the patient's experience.
综合药物审查是一种以患者为中心的方法,旨在优化药物使用并改善患者的治疗效果。本研究概述了一种试点护理模式,其中远程企业临床药剂师为一组复杂的家庭初级保健(HBPC)患者实施综合药物审查。
对 96 名患有复杂疾病的患者进行药物相关问题评估。收集这些患者的数据包括:慢性疾病数量、药物数量、每种药物的适当适应症、剂量适宜性、药物相互作用、药物优化和减少药物建议。分析 HBPC 实践接受的建议数量。
平均而言,患者年龄为 82 岁,患有 13 种慢性疾病。他们平均服用 17 种药物。在四个月的试点期间,共提出了 175 项药物建议,其中 53 项(30.3%)被接受,最常见的是药物停药、减少药物和剂量调整。64 名(66.7%)患者正在使用一种被列为不适合老年人使用的药物。最常见的潜在不适当药物是质子泵抑制剂(38.5%),其次是阿司匹林(24%)、曲马多(15.6%)、苯二氮䓬类(13.5%)或阿片类药物(8.3%)。建议减少 81 种药物的使用,并停止使用 27 种药物(33.3%)。建议调整 24 种剂量,调整 11 种药物(45.8%)。建议增加 34 种药物治疗方案,增加 2 种药物(5.9%)。
药剂师的综合药物审查是 HBPC 医疗保健连续性的必要组成部分。需要进一步研究,以检验将药剂师与 HBPC 支持相匹配是否能改善临床结果、降低医疗支出和改善患者体验。