Hallands Hospital Varberg, Varberg, Sweden.
School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
PLoS One. 2021 May 25;16(5):e0252037. doi: 10.1371/journal.pone.0252037. eCollection 2021.
Hypertension is one of the largest contributors to the disease burden and a major economic challenge for health-care systems. Early detection of persons with high blood pressure can be achieved through screening and has the potential to reduce morbidity and mortality. We evaluate the cost-effectiveness of an opportunistic hypertension screening programme in a dental-care facility for individuals aged 40-75 in comparison to care as usual (the no-screening baseline scenario).
A cost-effectiveness analysis (CEA) was carried out from the payer and societal perspectives, and the short-term (from screening until diagnosis has been established) cost per identified case of hypertension and long-term (20 years) cost per quality-adjusted life year (QALY) were reported. Data on the short-term cost were based on a real-world screening programme in which 2025 healthy individuals were screened for hypertension. Data on the long-term cost were based on the short-term outcomes combined with modelling in a Markov cohort model. Deterministic and probabilistic sensitivity analyses were carried out to assess uncertainty.
The short-term analysis showed an additional cost of 4,800 SEK (€470) per identified case of hypertension from the payer perspective and from the societal perspective 12,800 SEK (€1,240). The long-term analysis showed a payer cost per QALY of 2.2 million SEK (€210,000) and from the societal perspective 2.8 million SEK per QALY (€270,000).
The long-term model results showed that the screening model is unlikely to be cost-effective in a country with a well-developed health-care system and a relatively low prevalence of hypertension.
高血压是导致疾病负担的最大因素之一,也是医疗保健系统面临的主要经济挑战。通过筛查可以早期发现高血压患者,从而降低发病率和死亡率。我们评估了在牙科保健机构中对 40-75 岁人群进行机会性高血压筛查方案的成本效益,与常规护理(不筛查的基线情况)相比。
从支付者和社会角度进行了成本效益分析(CEA),并报告了每例确诊高血压病例的短期(从筛查到确诊)成本和每例质量调整生命年(QALY)的长期(20 年)成本。短期成本数据基于一项真实世界的筛查计划,该计划对 2025 名健康个体进行了高血压筛查。长期成本数据基于短期结果,并结合 Markov 队列模型进行建模。进行了确定性和概率敏感性分析以评估不确定性。
短期分析显示,从支付者角度来看,每确诊一例高血压病例会增加 4800 瑞典克朗(470 欧元)的成本,从社会角度来看则会增加 12800 瑞典克朗(1240 欧元)。长期分析显示,支付者每 QALY 的成本为 220 万瑞典克朗(21 万欧元),从社会角度来看则为每 QALY 280 万瑞典克朗(27 万欧元)。
长期模型结果表明,在医疗保健系统发达且高血压患病率相对较低的国家,筛查模型不太可能具有成本效益。