[新型化合物的诱变效应。IV. 5,6-二氢-7H-苯并(c)咔唑羧酸二烷基氨基乙酯的诱变效应]
[Mutagenic effect of new chemical compounds. IV. Mutagenic effect of dialkylaminoethyl esters of 5,6-dihydro-7H-benz(c)carbazol-carboxylic acids].
作者信息
Paronikian G M, Akopian L G, Dabrinian G A, Tumasian E A
出版信息
Genetika. 1977;13(9):1621-5.
PMID:340341
Abstract
The mutagenic effect of dialkylaminoet hyl esters of 5,6-dihydro-7H-benz(c)carbazole-carboxylic acids on biochemical mutants (Escherichia coli P-678, Actinomyces rimosus 222) is found. Hydrochloride of diethylaminoethyl ester of 5,6-dihydro-7H-benz(c)carbazole-9-carboxylic acid, which induced reversible and direct mutations, proved to be the most active compound, its mutagenic activity exceeding considerably the activity of ethylene imine.
摘要
发现了5,6-二氢-7H-苯并(c)咔唑-羧酸的二烷基氨基乙酯对生化突变体（大肠杆菌P-678、龟裂链霉菌222）的诱变作用。5,6-二氢-7H-苯并(c)咔唑-9-羧酸二乙氨基乙酯盐酸盐可诱导可逆和直接突变，被证明是最具活性的化合物，其诱变活性大大超过乙烯亚胺的活性。
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