Paronikian G M, Akopian L G, Tumasian E A, Dabrinian G A
Genetika. 1975;11(10):105-10.
The mutagenic effect of 21 new hydroxylamine derivatives was studied on biochemical mutants of Escherichia coli P-678 and Actinomyces rimosus 222. The Iver--Szybalsky method was used for the preliminary selection of mutagens. Dose-effect curves were plotted for the most efficient mutagens. Among the compounds studied 4 hydroxylamine derivatives were observed to have a mutagenic effect. The most efficient among them proved to be 0-(4-metoxybenzyl)-hydroxylamine and 0-(gamma-chlorocrotyl) hydroxylamine that induced reversions in the threonine locus of E. coli P-678 and in the lysine locus of Act. rimosus 222, being more efficient than hydroxylamine, the generally known mutagen. The dependence of the mutagenic activity of the compounds studied on their chemical structure is investigated.
研究了21种新型羟胺衍生物对大肠杆菌P-678和龟裂链霉菌222生化突变体的诱变作用。采用伊弗-齐巴尔茨基方法对诱变剂进行初步筛选。绘制了最有效诱变剂的剂量效应曲线。在所研究的化合物中，观察到4种羟胺衍生物具有诱变作用。其中最有效的是0-（4-甲氧基苄基）-羟胺和0-（γ-氯巴豆基）羟胺，它们在大肠杆菌P-678的苏氨酸位点和龟裂链霉菌222的赖氨酸位点诱导回复突变，比一般已知的诱变剂羟胺更有效。研究了所研究化合物的诱变活性与其化学结构的关系。
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