Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital and School of Medicine, Pusan National University, Busan, Republic of Korea.
Department of Electronic Engineering, Pai Chai University, Daejeon, Republic of Korea.
Neuroendocrinology. 2022;112(4):338-344. doi: 10.1159/000517319. Epub 2021 May 25.
Eating behavior is determined by both homeostatic and hedonic values.
We investigated the association of hedonic value with striatal dopamine transporter (DAT) availability sub-regionally.
An intravenous bolus injection of 18F-FP-CIT was administered after the infusion of glucose or placebo, and the emission data were acquired over 90 min. DAT availability and binding potential (BPND) were measured via the simplified reference tissue method. Subjects were assessed with sensory taste test of sucrose solutions. The "most liked" sucrose concentration (%) was determined as the hedonic rating for sucrose.
Twenty healthy males participated in this study. After glucose loading, BPNDs of putamen significantly increased, and those of caudate nucleus showed the increasing trend, while those of ventral striatum were not significantly different. After glucose loading, the "most liked" sucrose concentration (%) was negatively associated with BPNDs of caudate nucleus and showed the trend of positive association with those from ventral striatum. Slopes of regression lines were significantly different according to the sub-regions of striatum.
We have highlighted that striatal DAT increased after glucose loading in dorsal striatum, not in ventral striatum. These changes of striatal DAT were sub-regionally associated with the hedonic rating of sucrose from each subject.
进食行为受内稳态和享乐价值的影响。
本研究旨在探讨愉悦价值与纹状体多巴胺转运体（DAT）各亚区分布的相关性。
静脉注射 18F-FP-CIT 后，给予葡萄糖或安慰剂输注，并在 90 分钟内采集发射数据。通过简化参照组织法测量 DAT 摄取率和结合潜能（BPND）。通过蔗糖溶液的感官味觉测试评估受试者。“最喜爱”的蔗糖浓度（%）被确定为蔗糖的愉悦评分。
20 名健康男性参与了本研究。葡萄糖负荷后，壳核的 BPND 显著增加，尾状核的 BPND 呈增加趋势，而腹侧纹状体的 BPND 无显著差异。葡萄糖负荷后，“最喜爱”的蔗糖浓度（%）与尾状核的 BPND 呈负相关，与腹侧纹状体的 BPND 呈正相关趋势。根据纹状体的不同亚区，回归线的斜率存在显著差异。
本研究强调了葡萄糖负荷后背侧纹状体的 DAT 增加，而腹侧纹状体则没有。这些纹状体 DAT 的变化与每个受试者的蔗糖愉悦评分存在亚区相关性。
