Gastroenterology and Endoscopy Unit, University Hospital of Parma, University of Parma, Parma, Italy.
Gastroenterology Unit, Hospital Garcia Orcoyen, Estella, Spain.
Eur J Gastroenterol Hepatol. 2021 Jul 1;33(7):949-955. doi: 10.1097/MEG.0000000000002200.
In recent years, panintestinal capsule endoscopy (PCE) with double-headed capsules has been used to perform complete, single-sitting exploration of both small bowel and colon in different clinical conditions. Double-headed capsules for colonic examination (CCE) have been exploited first in this setting, followed by newer generations of capsules (i.e. PillCam Crohn, PCC) specifically engineered for this purpose. The aim of this study was to evaluate the feasibility of PCE in the form of a systematic review. We performed a comprehensive literature search to identify papers in which CE was specifically used for a PCE of the gastrointestinal tract. Data on CE, bowel preparation regimen, rate of cleanliness and completeness, and data on transit times were analyzed. The primary outcome was to assess the feasibility of a whole-gut exploration with CE. Sixteen (n = 16) studies including 915 CE procedures with CCE1 (n = 134), CCE2 (n = 357) and PCC (n = 424) were included. 13/16 studies were performed in the setting of Crohn's disease. Cleanliness and completeness rates were acceptable in all studies, ranging from 63.9% and 68.6% to 100%, respectively. In conclusion, PCE is a feasible technique, although further structured studies are needed to explore its full potential.
近年来，双头胶囊式全消化道胶囊内镜（PCE）已被用于在不同临床情况下对小肠和结肠进行完整的单次检查。首先在这种情况下开发了用于结肠检查的双头胶囊（CCE），随后又开发了新一代胶囊（即 PillCam Crohn，PCC），专门为此目的设计。本研究旨在通过系统评价评估 PCE 的可行性。我们进行了全面的文献检索，以确定专门用于 PCE 胃肠道检查的论文。分析了 CE、肠道准备方案、清洁度和完整性率以及传输时间的数据。主要结果是评估 CE 进行全胃肠道检查的可行性。纳入了 16 项（n = 16）研究，其中包括 915 例 CCE1（n = 134）、CCE2（n = 357）和 PCC（n = 424）的 CE 检查。13/16 项研究是在克罗恩病的背景下进行的。所有研究的清洁度和完整性率均可以接受，分别为 63.9%和 68.6%至 100%。总之，PCE 是一种可行的技术，但需要进一步的结构化研究来探索其全部潜力。
