Gheju Adelina, Jurescu Aura, Tăban Sorina, Al-Jobory Diana, Lazăr Fulger, Dema Alis
Department of Pathology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Department of Pathology, Emergency Clinical County Hospital "Pius Brinzeu", Timisoara, Romania.
J Int Med Res. 2021 May;49(5):3000605211016630. doi: 10.1177/03000605211016630.
In 2018, colorectal cancer (CRC) was the second most frequent malignancy in Romania after lung cancer. Although CRC is typically encountered in patients >50 years old, CRC's global incidence among younger adults has been increasing. We aimed to compare the disease characteristics of patients with CRC aged ≤50 years with those >50 years old.
We retrospectively evaluated data from patients with CRC who underwent standard surgery at "Pius Brinzeu" Emergency County Hospital, Timisoara, Romania. Patients were divided into two groups: Group 1 (patients ≤50 years old) and Group 2 (patients >50 years old). Six parameters were analyzed (sex, residence location, age, tumor localization, microscopic findings, pathological staging).
Data on age-related CRC were available for 1380 patients treated from January 2012 to December 2018. Group 1 included 120 patients while group 2 included 1260 patients. Significantly more Group 1 patients presented with advanced CRC compared with Group 2 patients (94.2% vs. 87.4%). Furthermore, CRC in younger adults was more likely to be diagnosed at an advanced stage.
Monitoring the CRC incidence in younger adults is essential to assess whether screening practices require changes and to raise awareness among clinicians of the increasing CRC incidence among younger patients.
2018年，结直肠癌（CRC）是罗马尼亚仅次于肺癌的第二常见恶性肿瘤。尽管CRC通常在50岁以上的患者中出现，但CRC在年轻成年人中的全球发病率一直在上升。我们旨在比较年龄≤50岁的CRC患者与年龄>50岁的患者的疾病特征。
我们回顾性评估了在罗马尼亚蒂米什瓦拉的“皮乌斯·布林泽乌”县急救医院接受标准手术的CRC患者的数据。患者分为两组：第1组（年龄≤50岁的患者）和第2组（年龄>50岁的患者）。分析了六个参数（性别、居住地点、年龄、肿瘤定位、显微镜检查结果、病理分期）。
2012年1月至2018年12月期间接受治疗的1380例患者有与年龄相关的CRC数据。第1组包括120例患者，第2组包括1260例患者。与第2组患者相比，第1组中晚期CRC患者明显更多（94.2%对87.4%）。此外，年轻成年人中的CRC更有可能在晚期被诊断出来。
监测年轻成年人中的CRC发病率对于评估筛查方法是否需要改变以及提高临床医生对年轻患者中CRC发病率上升的认识至关重要。
