Andersen Stine Linding, Nielsen Kasper Krogh, Kristensen Søren Risom
Department of Clinical Biochemistry, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Sdr. Skovvej 15, 9000 Aalborg, 9000, Aalborg, Denmark.
Thyroid Res. 2021 May 25;14(1):12. doi: 10.1186/s13044-021-00102-4.
Pregnancy induces physiological changes that affect the risk of thrombosis and thyroid disease. In this hypothesis-generating review, the physiological changes in the coagulation system and in thyroid function during a normal pregnancy are described, and the incidence of venous thromboembolism (VTE) and thyroid disease in and after a pregnancy are compared and discussed. Furthermore, evidence regarding the association between thyroid disease and VTE in non-pregnant individuals is scrutinized. In conclusion, a normal pregnancy entails hormonal changes, which influence the onset of VTE and thyroid disease. Current evidence suggests an association between thyroid disease and VTE in non-pregnant individuals. This review proposes the hypothesis that maternal thyroid disease associates with VTE in pregnant women and call for future research studies on this subject. If an association exists in pregnant women specifically, such findings may have clinical implications regarding strategies for thyroid function testing and potential thromboprophylaxis in selected individuals.
怀孕会引发一些生理变化，这些变化会影响血栓形成和甲状腺疾病的风险。在这篇提出假设的综述中，描述了正常孕期凝血系统和甲状腺功能的生理变化，并对孕期及产后静脉血栓栓塞症（VTE）和甲状腺疾病的发病率进行了比较和讨论。此外，还详细审查了非孕期个体中甲状腺疾病与VTE之间关联的证据。总之，正常怀孕会带来激素变化，这些变化会影响VTE和甲状腺疾病的发病。目前的证据表明非孕期个体中甲状腺疾病与VTE之间存在关联。本综述提出了一个假设，即孕妇的甲状腺疾病与VTE有关，并呼吁对此主题进行未来的研究。如果在孕妇中确实存在这种关联，那么这些发现可能对甲状腺功能检测策略以及特定个体的潜在血栓预防具有临床意义。
