Doerschuk C M, Allard M F, Lee S, Brumwell M L, Hogg J C
University of British Columbia Pulmonary Research Laboratory, Vancouver, Canada.
J Appl Physiol (1985). 1988 Jul;65(1):401-7. doi: 10.1152/jappl.1988.65.1.401.
The effect of epinephrine on neutrophil (PMN) kinetics in rabbit lungs was evaluated by measuring the retention of radiolabeled PMN's in the lung, the exchange rate between the marginated and circulating pools of PMN's, and the erythrocyte (RBC) transit time. Epinephrine treatment decreased RBC transit times and increased exchange rates in the regions with the shortest transit times but did not change the pulmonary recovery of radiolabeled PMN's. When regions of similar RBC transit time were compared, epinephrine did not affect PMN retention at short transit times but did produce greater retention at long transit times. These data suggest that the major effect of epinephrine was to increase the proportion of the lung having short RBC transit times and fast exchange rates between the marginated and circulating pools. However, this effect did not decrease the overall retention of PMN's most likely because it was balanced by recruitment of additional capillary segments, which increased PMN retention in regions with longer transit times.
通过测量放射性标记的中性粒细胞在肺内的滞留情况、中性粒细胞边缘池与循环池之间的交换率以及红细胞（RBC）通过时间，评估肾上腺素对兔肺中性粒细胞（PMN）动力学的影响。肾上腺素治疗缩短了红细胞通过时间，并增加了通过时间最短区域的交换率，但并未改变放射性标记中性粒细胞的肺内恢复情况。当比较红细胞通过时间相似的区域时，肾上腺素在短通过时间时不影响中性粒细胞滞留，但在长通过时间时确实导致更大的滞留。这些数据表明，肾上腺素的主要作用是增加肺内红细胞通过时间短且边缘池与循环池之间交换率快的比例。然而，这种作用并未降低中性粒细胞的总体滞留，最可能的原因是它被额外毛细血管段的募集所平衡，这增加了通过时间较长区域的中性粒细胞滞留。
