Louiselle Katie, Harte Lory, Thompson Charity, Pabst Damon, Calvert Andrea, Patterson Mark E
J Pediatr Pharmacol Ther. 2021;26(4):384-394. doi: 10.5863/1551-6776-26.4.384. Epub 2021 May 19.
Children with epilepsy are at increased risk of medication errors due to disease complexity and administration of time-sensitive medication. Errors frequently occur during transitions of care between home and hospital, a time when accuracy of medication history lists is difficult to ascertain. Adverse events likely from medication discrepancies underscore the importance of improving medication reconciliation upon inpatient intake. This quality improvement project was designed to evaluate and optimize the current medication history process in epileptic patients upon hospital admission at a pediatric academic hospital.
A retrospective chart review was conducted on 30 patients with epilepsy admitted in during April, July, and October 2018 to identify unintentional medication discrepancies among 6 sources: documented medication history, inpatient orders from the electronic medical record, outpatient clinic notes, inpatient history and admission document, phone message records, and external insurance claims.
A total of 63% percent of patients had at least 1 unintentional medication discrepancy. Most discrepancies occurred with daily maintenance anticonvulsants (63%). The most common types were omission of medication history (31%) and inpatient order omissions (27%). The number of medication histories completed with at least 1 discrepancy varied across pharmacists, nurses, and physicians, yet differences were not statistically significant.
Our study found a higher incidence of anticonvulsant discrepancies compared with previous studies. This quality improvement initiative identified the absence of a standardized process as the root cause for the high incidence of anticonvulsant discrepancies in pediatric patients with epilepsy at hospital admission.
由于疾病的复杂性以及需要按时给药,癫痫患儿发生用药错误的风险增加。在家庭与医院之间的护理转接过程中经常出现错误,而在此期间,用药史清单的准确性很难确定。可能因用药差异导致的不良事件凸显了在住院时改进用药核对的重要性。本质量改进项目旨在评估并优化一家儿科教学医院癫痫患者入院时的当前用药史流程。
对2018年4月、7月和10月收治的30例癫痫患者进行回顾性病历审查,以确定6个来源中的无意用药差异:记录的用药史、电子病历中的住院医嘱、门诊病历、住院病史和入院文件、电话留言记录以及外部保险理赔。
共有63%的患者至少存在1处无意用药差异。大多数差异发生在每日维持性抗惊厥药物方面(63%)。最常见的类型是用药史遗漏(31%)和住院医嘱遗漏(27%)。不同药剂师、护士和医生完成的存在至少1处差异的用药史数量有所不同,但差异无统计学意义。
我们的研究发现,与之前的研究相比,抗惊厥药物差异的发生率更高。这项质量改进举措确定缺乏标准化流程是癫痫患儿入院时抗惊厥药物差异发生率高的根本原因。