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不对称四齿席夫碱铜（II）和铁（III）配合物的合成、表征及细胞毒性

Synthesis, Characterization, and Cytotoxicity of Unsymmetrical Tetradentate Schiff Base Cu(II) and Fe(III) Complexes.

作者信息

Nguyen Quang Trung, Pham Thi Phuong Nam, Nguyen Van Tuyen

机构信息

Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.

出版信息

Bioinorg Chem Appl. 2021 May 3;2021:6696344. doi: 10.1155/2021/6696344. eCollection 2021.

DOI:10.1155/2021/6696344
PMID:34035799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8118743/
Abstract

Unsymmetrical tetradentate Schiff base Fe(III) and Cu(II) complexes were prepared by the coordination of some unsymmetrical tetradentate Schiff base ligands with CuCl·2HO or FeCl·6HO. The obtained complexes were characterized by ESI-MS, IR, and UV-Vis. The spectroscopic data with typical signals are in agreement with the suggested molecular formulae of the complexes. Their cyclic voltammetric studies in acetonitrile solutions showed that the Cu(II)/Cu(I) and Fe(III)/Fe(II) reduction processes are at (-)1.882-(-) 1.782 V and at (-) 1.317-(-) 1.164 V, respectively. The cytotoxicity of obtained complexes was screened for KB and Hep-G2 human cancer cell lines. The results showed that almost unsymmetrical tetradentate Schiff base complexes have good cytotoxicity. The synthetic complexes bearing the unsymmetrical tetradentate Schiff base ligands with different substituted groups in the salicyl ring indicate different cytotoxicity. The obtained Fe(III) complexes are more cytotoxic than Cu(II) complexes and relative unsymmetric Schiff base ligands.

摘要

通过一些不对称四齿席夫碱配体与CuCl·2H₂O或FeCl₃·6H₂O配位制备了不对称四齿席夫碱铁（III）和铜（II）配合物。通过电喷雾质谱（ESI-MS）、红外光谱（IR）和紫外可见光谱（UV-Vis）对所得配合物进行了表征。具有典型信号的光谱数据与所提出的配合物分子式一致。它们在乙腈溶液中的循环伏安研究表明，Cu（II）/Cu（I）和Fe（III）/Fe（II）还原过程分别在（-）1.882 - （-）1.782 V和（-）1.317 - （-）1.164 V。对所得配合物针对KB和Hep-G2人癌细胞系进行了细胞毒性筛选。结果表明，几乎所有不对称四齿席夫碱配合物都具有良好的细胞毒性。在水杨环中带有不同取代基的不对称四齿席夫碱配体的合成配合物表现出不同的细胞毒性。所得铁（III）配合物比铜（II）配合物和相对不对称的席夫碱配体具有更强的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/b06e1fff2c60/BCA2021-6696344.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/ea839216f3f4/BCA2021-6696344.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/561184b1045e/BCA2021-6696344.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/2c8e9ced5843/BCA2021-6696344.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/99497b54dbdc/BCA2021-6696344.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/5edb07b9383f/BCA2021-6696344.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/b06e1fff2c60/BCA2021-6696344.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/ea839216f3f4/BCA2021-6696344.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/561184b1045e/BCA2021-6696344.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/2c8e9ced5843/BCA2021-6696344.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/99497b54dbdc/BCA2021-6696344.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/5edb07b9383f/BCA2021-6696344.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdde/8118743/b06e1fff2c60/BCA2021-6696344.005.jpg

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