Jicsinszky László, Martina Katia, Cravotto Giancarlo
Dept. of Drug Science and Technology, University of Turin, Via Giuria 9, 10125, Torino, Italy.
J Drug Deliv Sci Technol. 2021 Aug;64:102589. doi: 10.1016/j.jddst.2021.102589. Epub 2021 May 20.
The main antiviral drug-cyclodextrin interactions, changes in physicochemical and physiological properties of the most commonly used virucides are summarized. The potential complexation of antiviral molecules against the SARS-Cov2 also pointed out the lack of detailed information in designing effective and general medicines against viral infections. The principal problem of the current molecules is the 3D structures of the currently active compounds. Improving the solubility or bioavailability of antiviral molecules is possible, however, there is no universal solution, and the complexation experiments dominantly use the already approved cyclodextrin derivatives. This review discusses the basic properties of the different cyclodextrin derivatives, their potential in antiviral formulations, and the prevention and treatment of viral infections. The biologically active new cyclodextrin derivatives are also discussed.
总结了主要的抗病毒药物与环糊精的相互作用，以及最常用的杀病毒剂的物理化学和生理性质的变化。抗病毒分子与新冠病毒的潜在络合作用也指出，在设计针对病毒感染的有效通用药物方面缺乏详细信息。当前分子的主要问题是目前活性化合物的三维结构。提高抗病毒分子的溶解度或生物利用度是可能的，然而，没有通用的解决方案，并且络合实验主要使用已获批的环糊精衍生物。本综述讨论了不同环糊精衍生物的基本性质、它们在抗病毒制剂中的潜力以及病毒感染的预防和治疗。还讨论了具有生物活性的新型环糊精衍生物。
