Lehmann Anouk, Späni Selina, Harings-Kaim Annette, Probst Cecilia, Christ Andreas, Leuppi-Taegtmeyer Anne B
Medical University Clinic, Cantonal Hospital Baselland, Liestal, Switzerland.
Hospital Pharmacy, Cantonal Hospital Baselland, Liestal, Switzerland.
Glob Cardiol Sci Pract. 2021 Apr 30;2021(1):e202102. doi: 10.21542/gcsp.2021.2.
We present the case of a 34-year-old woman with recurrent depressive disorder who ingested purple foxglove with suicidal intent. She bought a foxglove plant over the internet and used all of its leaves to make a tea that she then drank over a period of a few hours. Seventeen hours later, she developed abdominal pain, emesis and bradycardia and was admitted via the emergency department to the intensive care unit for further treatment and monitoring. The plasma digoxin concentration measured 3.53 nmol/l (therapeutic reference range 0.77-1.50 nmol/l) 21 hours after ingestion of the tea. She remained heamodynamically and neurologically stable, was treated with antiemetics and simple analgesia and did not require digoxin-specific antibodies. Despite normal renal function, her plasma digoxin half-life was prolonged (estimated 76 h), reflecting the long half-life of the parent compound digitoxin which is the main cardiac glycoside in . She was transferred to psychiatric care 48 h after admission. In this report, we compare this case to other similar cases, which to date have only been rarely reported in the literature.
我们报告一例34岁复发性抑郁症女性患者,其出于自杀意图服用了紫花洋地黄。她通过互联网购买了一株洋地黄植物,并使用其所有叶子煮茶,在几个小时内喝完。17小时后,她出现腹痛、呕吐和心动过缓,通过急诊科被收入重症监护病房进行进一步治疗和监测。饮用茶21小时后测得血浆地高辛浓度为3.53 nmol/l(治疗参考范围为0.77 - 1.50 nmol/l)。她的血流动力学和神经功能保持稳定,接受了止吐药和简单镇痛治疗,不需要地高辛特异性抗体。尽管肾功能正常,但她的血浆地高辛半衰期延长(估计为76小时),这反映了母体化合物洋地黄毒苷的长半衰期,洋地黄毒苷是其主要的强心苷。入院48小时后她被转至精神科护理。在本报告中,我们将此病例与其他类似病例进行比较,此类病例迄今为止在文献中鲜有报道。