Rajakrishnan R, Alfarhan A H, Al-Ansari A M, Lekshmi R, Sreelakshmi R, Benil P B, Kim Y-O, Tack J-C, Na S W, Kim H-J
Dept. of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, Saudi Arabia.
Dept. of Botany and Biotechnology, MSM College, Kayamkulam, Kerala, India.
Saudi J Biol Sci. 2020 Apr;27(4):1124-1129. doi: 10.1016/j.sjbs.2019.12.025. Epub 2019 Dec 23.
The phenomenal increase in the demand of herbal drugs, leads to over exploitation of medicinal plants which ultimately resulted in the scarcity and endangerment of many valuable plant species. On observing the difficulties in procuring genuine herbal drugs arose the concept of substitution which was documented in many classical Ayurvedic texts. The present study made a comparative evaluation of the gastroprotective potential of hydroalcoholic extracts of an original drug (HAAH) and its substitute (HACR) in the treatment of gastric ulcer under experimental conditions. The anti-ulcer property of the plant extracts was investigated against pylorus ligation induced ulcer in Wistar albino rats. The results confirmed that both and deliver comparable significant protection against gastric ulcer, indicated by a decrease in the free and total acidity, volume of gastric content, total proteins and increase in pH of gastric content, total carbohydrates and total carbohydrates to total proteins ratio. The observed anti-ulcer potential of both the drugs is attributed mainly to prevention of the generation of damaging free radical cascades and oxidant radical release.
草药需求的显著增长导致了药用植物的过度开发，最终致使许多珍贵植物物种稀缺并濒临灭绝。在观察到获取正宗草药存在困难后，便产生了替代的概念，这在许多经典阿育吠陀文献中都有记载。本研究对一种原药（HAAH）及其替代品（HACR）的水醇提取物在实验条件下治疗胃溃疡的胃保护潜力进行了比较评估。针对Wistar白化大鼠幽门结扎诱导的溃疡，研究了植物提取物的抗溃疡特性。结果证实，HAAH和HACR对胃溃疡均具有相当显著的保护作用，表现为游离酸度和总酸度、胃内容物体积、总蛋白降低，胃内容物pH值、总碳水化合物以及总碳水化合物与总蛋白比值升高。观察到的两种药物的抗溃疡潜力主要归因于防止破坏性自由基级联反应的产生和氧化自由基的释放。
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