Industrial Biotechnology and Biocatalysis Group, Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, 15780 Athens, Greece.
TECNALIA, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Álava, Leonardo Da Vinci 1, 01510 Miñano, Álava, Spain.
FEMS Microbiol Lett. 2021 May 29;368(9). doi: 10.1093/femsle/fnab054.
The establishment of a sustainable circular bioeconomy requires the effective material recycling from biomass and biowaste beyond composting/fertilizer or anaerobic digestion/bioenergy. Recently, volatile fatty acids attracted much attention due to their potential application as carbon source for the microbial production of high added-value products. Their low-cost production from different types of wastes through dark fermentation is a key aspect, which will potentially lead to the sustainable production of fuels, materials or chemicals, while diminishing the waste volume. This article reviews the utilization of a volatile fatty acid platform for the microbial production of polyhydroxyalkanoates, single cell oil and omega-3 fatty acids, giving emphasis on the fermentation challenges for the efficient implementation of the bioprocess and how they were addressed. These challenges were addressed through a research project funded by the European Commission under the Horizon 2020 programme entitled 'VOLATILE-Biowaste derived volatile fatty acid platform for biopolymers, bioactive compounds and chemical building blocks'.
建立可持续的循环生物经济需要有效地从生物质和生物废物中进行物质回收，超越堆肥/肥料或厌氧消化/生物能源。最近，由于它们作为微生物生产高附加值产品的碳源的潜在应用，挥发性脂肪酸引起了广泛关注。通过黑暗发酵从不同类型的废物中低成本生产是一个关键方面，这将有可能导致燃料、材料或化学品的可持续生产，同时减少废物量。本文综述了利用挥发性脂肪酸平台微生物生产聚羟基烷酸酯、单细胞油和ω-3 脂肪酸的情况，重点介绍了发酵方面的挑战，以及如何解决这些问题，以有效地实施生物工艺。这些挑战是通过欧洲委员会在“地平线 2020”计划下资助的一个研究项目来解决的，该项目题为“VOLATILE-生物废物衍生的挥发性脂肪酸平台，用于生物聚合物、生物活性化合物和化学结构单元”。
