Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, Fujian 361102, P.R. China.
Medical College of Guangxi University, Nanning, Guangxi 530004, P.R. China.
Int J Oncol. 2021 Jul;59(1). doi: 10.3892/ijo.2021.5226. Epub 2021 May 26.
Tumour necrosis factor (TNF)‑α‑inducible protein 8 (TNFAIP8) is the founding member of the TIPE family. According to accumulating evidence, TNFAIP8 plays a pivotal role in the regulation of a variety of tumours, as well as inflammatory diseases. TNFAIP8 is suggested to act as an anti‑apoptotic protein, affecting proliferation, metastasis, invasion, angiogenesis, drug resistance and immune response through multiple signalling pathways. From the clinical point of view, further studies should be required to confirm the prognostic value of TNFAIP8 and also clarify its possible contribution to the development of a novel therapeutic strategy to treat patients with tumours, including those of the breast, colon and lung, and inflammatory diseases. The present review focuses on the TIPE family member TNFAIP8 and describes the molecular mechanisms with regard to how TNFAIP8 could participate in the development of tumours as well as other conditions.
肿瘤坏死因子 (TNF)‑α 诱导蛋白 8（TNFAIP8）是 TIPE 家族的创始成员。根据不断积累的证据，TNFAIP8 在多种肿瘤以及炎症性疾病的调控中发挥着关键作用。TNFAIP8 被认为是一种抗凋亡蛋白，通过多种信号通路影响增殖、转移、侵袭、血管生成、耐药性和免疫反应。从临床角度来看，需要进一步的研究来确认 TNFAIP8 的预后价值，并阐明其对开发治疗包括乳腺癌、结肠癌和肺癌在内的肿瘤以及炎症性疾病的新型治疗策略的可能贡献。本综述重点介绍了 TIPE 家族成员 TNFAIP8，并描述了 TNFAIP8 可能参与肿瘤发生以及其他疾病的分子机制。
