Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, Binsheng Road 3399#, Hangzhou, 310051, Zhejiang Province, China.
Eye Center of the 2nd Affiliated Hospital, School of Medicine, Zhejiang Provincial Key Lab of Ophthalmology, Zhejiang University, Jiefang Road 88#, Hangzhou, 310009, Zhejiang Province, China.
Environ Sci Pollut Res Int. 2021 Oct;28(38):53605-53613. doi: 10.1007/s11356-021-14009-y. Epub 2021 May 25.
The objective of this study was to investigate the association between ambient particulate matters (PMs) and chronic obstructive pulmonary disease (COPD) mortality. generalized additive mixed model was employed to investigate the effects of ambient fine and coarse PMs on COPD mortality using 13,066 deaths from 2014 to 2016 among six cities in Zhejiang Province in Southeastern China. The daily average death count due to COPD was 3, varying from 1 to 7 among six cities. The daily 24-h mean concentrations were diverse among cities, from 29.7 to 56.8 μg/m for PM, 16.7 to 30.3 μg/m for PM, and 50.3 to 87.1 μg/m for PM, respectively. The analysis showed that daily exposure to PM and PM was associated with increased mortality due to COPD and that weak effects were observed between PM and COPD mortality. Our results provided solid evidence that the fine particles in air pollution have stronger functions on adverse health effects other than coarser particles in Southeastern China, which may be considered as a potential clinic target in PM-associated COPD.
本研究旨在探讨环境颗粒物（PM）与慢性阻塞性肺疾病（COPD）死亡率之间的关联。采用广义加性混合模型，利用中国东南部浙江省六个城市 2014 年至 2016 年的 13066 例死亡数据，研究了环境细颗粒物和粗颗粒物对 COPD 死亡率的影响。六个城市 COPD 每日平均死亡人数为 3 人，从 1 人到 7 人不等。城市间的 24 小时平均浓度差异较大，PM 为 29.7 至 56.8μg/m，PM 为 16.7 至 30.3μg/m，PM 为 50.3 至 87.1μg/m。分析表明，每日暴露于 PM 和 PM 与 COPD 死亡率增加有关，而 PM 与 COPD 死亡率之间的关系较弱。我们的结果提供了确凿的证据，表明在中国东南部，空气污染中的细颗粒物对健康的不良影响比粗颗粒物更强，这可能被视为与 PM 相关的 COPD 的一个潜在临床靶点。
