Department of Plastic and Reconstructive Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato City, Tokyo, 105-8461, Japan.
Department of Pathology, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato City, Tokyo, 105-8461, Japan.
Lasers Surg Med. 2021 Nov;53(9):1220-1226. doi: 10.1002/lsm.23412. Epub 2021 May 26.
To analyze histopathological changes and degree of damage to the axillary tissue due to single- and double-pass irradiation therapy using a microwave energy-based device. STUDY DESIGN/MATERIALS AND METHODS: We included 15 axillary hyperhidrosis and axillary osmidrosis patients who received microwave irradiation therapy between March 2017 and March 2019. Ten patients underwent single-pass irradiation and five underwent double-pass irradiation, after which skin samples were collected from the right and left axillae for pathological analysis. Samples were taken in a consistent manner from Patient 6 onwards and a comparative study of five single-pass and five double-pass patients was conducted (n = 10).
Histopathological analysis showed destruction and fibrosis in addition to necrosis and damage to the adipose tissue in apocrine and eccrine sweat glands. In the superficial microvasculature, blood vessel wall damage and thrombus formation were observed as well as damage in the hair follicles and hair bulbs. No obvious damage was observed in the epidermis and nerves. The amount of damage to sweat glands was higher in patients undergoing double-pass instead of single-pass irradiation.
From a histopathological point of view, microwave energy-based irradiation therapy can be considered efficient, as there was no damage to epidermis and nerves and favorable destruction of apocrine and eccrine glands. As the amount of damaged sweat glands was higher after double-pass irradiation, it can be considered more effective than single-pass irradiation. Lasers Surg. Med. © 2021 Wiley Periodicals LLC.
分析基于微波能量的设备进行单次和双次放射治疗对腋窝组织的组织病理学变化和损伤程度。
研究设计/材料和方法：我们纳入了 2017 年 3 月至 2019 年 3 月期间接受微波辐射治疗的 15 例腋窝多汗症和腋窝臭汗症患者。10 例患者接受单次放射治疗，5 例患者接受双次放射治疗，之后从右腋窝和左腋窝采集皮肤样本进行病理分析。从第 6 例患者开始，以一致的方式取样，并对 5 例单次放射治疗患者和 5 例双次放射治疗患者进行了比较研究（n=10）。
组织病理学分析显示，除了大汗腺和小汗腺的脂肪组织坏死和损伤外，还存在破坏和纤维化。在浅表微血管中，观察到血管壁损伤和血栓形成，以及毛囊和毛球损伤。表皮和神经未见明显损伤。双次放射治疗患者的汗腺损伤程度高于单次放射治疗患者。
从组织病理学角度来看，基于微波能量的放射治疗是有效的，因为它对表皮和神经没有损伤，并且大汗腺和小汗腺有良好的破坏。由于双次放射治疗后损伤的汗腺数量更多，因此它比单次放射治疗更有效。激光外科学杂志。2021 年 Wiley 期刊有限公司。
