BRIO：一个用于 RNA 序列和结构模体扫描的网络服务器。
BRIO: a web server for RNA sequence and structure motif scan.
机构信息
Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
IIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Italy.
出版信息
Nucleic Acids Res. 2021 Jul 2;49(W1):W67-W71. doi: 10.1093/nar/gkab400.
The interaction between RNA and RNA-binding proteins (RBPs) has a key role in the regulation of gene expression, in RNA stability, and in many other biological processes. RBPs accomplish these functions by binding target RNA molecules through specific sequence and structure motifs. The identification of these binding motifs is therefore fundamental to improve our knowledge of the cellular processes and how they are regulated. Here, we present BRIO (BEAM RNA Interaction mOtifs), a new web server designed for the identification of sequence and structure RNA-binding motifs in one or more RNA molecules of interest. BRIO enables the user to scan over 2508 sequence motifs and 2296 secondary structure motifs identified in Homo sapiens and Mus musculus, in three different types of experiments (PAR-CLIP, eCLIP, HITS). The motifs are associated with the binding of 186 RBPs and 69 protein domains. The web server is freely available at http://brio.bio.uniroma2.it.
RNA 与 RNA 结合蛋白 (RBP) 的相互作用在基因表达调控、RNA 稳定性以及许多其他生物过程中起着关键作用。RBP 通过结合特定的序列和结构基序来实现这些功能，这些基序是识别靶 RNA 分子的关键。因此，识别这些结合基序对于提高我们对细胞过程及其调控方式的认识至关重要。在这里，我们介绍 BRIO（BEAM RNA Interaction mOtifs），这是一个新的网络服务器，用于识别一个或多个感兴趣的 RNA 分子中的序列和结构 RNA 结合基序。BRIO 允许用户在三种不同类型的实验（PAR-CLIP、eCLIP、HITS）中扫描在智人和小鼠中鉴定出的 2508 个序列基序和 2296 个二级结构基序。这些基序与 186 个 RBP 和 69 个蛋白质结构域的结合有关。该网络服务器可在 http://brio.bio.uniroma2.it 免费获取。
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