Pediatr Ann. 2021 Mar;50(3):e105-e112. doi: 10.3928/19382359-20210218-01. Epub 2021 Mar 1.
Current scientific evidence has proven that atherosclerosis is a process that begins in childhood and tracks into adulthood, likely culminating in adverse cardiovascular events such as coronary artery disease, peripheral artery disease, and stroke. In addition, the obesity epidemic and increasing awareness of genetic lipid disorders has made the understanding and management of lipid disorders necessary for pediatricians. Childhood offers a unique opportunity for preventing, modifying, or eliminating risk factors and, in doing so, reversing or slowing the process of atherosclerosis. In general, management involves targeted lifestyle interventions such as strict dietary changes and increases in physical activity. In some circumstances, pharmacotherapy, even in childhood, is warranted. .
目前的科学证据已经证明,动脉粥样硬化是一个始于儿童期并持续到成年期的过程,很可能最终导致不良的心血管事件,如冠状动脉疾病、外周动脉疾病和中风。此外,肥胖症的流行和对遗传脂质紊乱的认识不断提高,使得儿科医生有必要了解和管理脂质紊乱。儿童期为预防、改变或消除风险因素提供了独特的机会,从而可以逆转或减缓动脉粥样硬化的进程。一般来说,管理包括有针对性的生活方式干预,如严格的饮食改变和增加身体活动。在某些情况下,即使在儿童期,也需要药物治疗。