Department of Pediatrics, Division of Cardiology, Nationwide Children's Hospital, Columbus, OH, USA.
Department of Pediatrics, Division of Cardiology, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, 49 N. Dunlap St, Memphis, TN, 38103, USA.
Curr Atheroscler Rep. 2024 Dec;26(12):693-700. doi: 10.1007/s11883-024-01244-0. Epub 2024 Oct 2.
Pediatric healthcare providers have increasingly become aware of the need for timely and informative transition of adolescents and young adults with chronic medical conditions such as diabetes and cystic fibrosis. However, there is paucity of published data on the importance of and most effective way to transition youth with lipid disorders who are at increased risk of premature cardiovascular disease.
Evidence shows that atherosclerosis begins at a young age. However, there are no guidelines on the transition of adolescents and young adults with dyslipidemia. In addition, there are conflicting guidelines for lipid management in children versus adults, despite advances in medical pharmacotherapies for dyslipidemia. The lack of guidelines for transition and discordant recommendations for management of this vulnerable population places young adults at-risk for worsening of their underlying disease, and premature cardiovascular events.
儿科保健医生越来越意识到需要及时为患有慢性疾病（如糖尿病和囊性纤维化）的青少年和年轻人提供信息丰富的过渡服务。然而，关于脂质紊乱且有过早发生心血管疾病风险的年轻人的过渡的重要性和最有效的方法，发表的数据却很少。
有证据表明，动脉粥样硬化在年轻时就开始了。然而，目前尚无关于脂质紊乱青少年和年轻人过渡的指南。此外，尽管在儿童和成人的血脂药物治疗方面取得了进展，但在儿童和成人的血脂管理方面仍存在指南冲突。缺乏过渡指南和对这一脆弱人群管理的不一致建议，使年轻人面临疾病恶化和过早发生心血管事件的风险。
