Fischer M, Falkensammer C
Int J Clin Pharmacol Biopharm. 1977 Dec;15(12):585-9.
Sixteen patients with different kinds of hyperlipidemia were treated with Atroplex (Mg-Chlorphenoxyisobutyrate 350 mg, Mesoinositol-Hexanicotinate 250 mg), a new serum lipid decreasing drug. Within an interval of 60 days' standard treatment of 3 tablets of Atroplex, the serum level of cholesterol was reduced by 16-20% and that of triglycerides by 36-49%. This significant effect was obvious over the whole period of treatment. According to the compound of Clofibrate, Atroplex interfered with the anticoagulant treatment with phenprocoumon. In spite of this an AC-therapy is possible during the Atroplex medication, if the AC doses are reduced by 30-50%.
16例患有不同类型高脂血症的患者接受了一种新型降血脂药物Atroplex(氯苯氧异丁酸镁350毫克,肌醇六烟酸酯250毫克)的治疗。在标准治疗的60天内,每天服用3片Atroplex,胆固醇血清水平降低了16 - 20%,甘油三酯水平降低了36 - 49%。在整个治疗期间,这种显著效果都很明显。根据安妥明的成分,Atroplex会干扰苯丙香豆素的抗凝治疗。尽管如此,在服用Atroplex期间,如果将抗凝剂剂量减少30 - 50%,还是可以进行抗凝治疗的。