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用氯苯氧异丁酸镁和肌醇六烟酸酯联合治疗各种类型的高脂蛋白血症(作者译)

[Treatment of various types of hyperlipoproteinaemia with a combination of Mg-chlorophenoxy-isobutyrate and mesoinositol-hexanicotinate (author's transl)].

作者信息

Bolzano K, Krempler F, Haslauer F

出版信息

Arzneimittelforschung. 1979;29(10):1621-4.

PMID:583231
Abstract

50 patients with different types of hyperlipoproteinaemia were treated with a combination of Mg-chlorophenoxyisobutyrate (700 mg) and mesoinositol-hexanicotinate (500 mg) (Atroplex) twice daily. 7 patients had type IIa, 39 patients type IIb or IV and 4 patients type V. After a period of one month without any treatment the patients were treated during two months. While the effects of this combination on cholesterol of type IIa patients was poor, the drug had an excellent lipid-lowering effect in the patients with type IIb, IV and V. After 14 days' treatment the plasma cholesterol and triglyceride levels in patients of type IIb or IV were significantly lowered. This effect became even more pronounced after one-month treatment. There was no significant difference between the effect of one-month treatment and that of two-month treatment. About two-thirds of the patients of type IIb or IV were responders. No serious side effects could be observed during our study.

摘要

50例不同类型的高脂蛋白血症患者接受了氯苯丁酯(700毫克)和肌醇六烟酸酯(500毫克)(阿托普lex)联合治疗,每日两次。其中7例为IIa型,39例为IIb型或IV型,4例为V型。在未经任何治疗一个月后,患者接受了为期两个月的治疗。虽然这种联合用药对IIa型患者的胆固醇效果不佳,但对IIb型、IV型和V型患者具有出色的降脂作用。治疗14天后,IIb型或IV型患者的血浆胆固醇和甘油三酯水平显著降低。这种效果在治疗一个月后变得更加明显。一个月治疗和两个月治疗的效果之间没有显著差异。大约三分之二的IIb型或IV型患者有反应。在我们的研究中未观察到严重的副作用。

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