人母乳外泌体可能预防早产儿坏死性小肠结肠炎。 - Suppr

Human breast milk exosomes may protect against necrotizing enterocolitis in preterm infants.

作者信息

Madden Jessica W

机构信息

Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.

出版信息

Pediatr Res. 2021 Aug;90(2):244-245. doi: 10.1038/s41390-021-01580-w. Epub 2021 May 26.

DOI:10.1038/s41390-021-01580-w

PMID:34040162

Abstract

摘要

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Human breast milk exosomes may protect against necrotizing enterocolitis in preterm infants.

Pediatr Res. 2021 Aug;90(2):244-245. doi: 10.1038/s41390-021-01580-w. Epub 2021 May 26.

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Concentrations of IL-10 in preterm human milk and in milk from mothers of infants with necrotizing enterocolitis.

Acta Paediatr. 2004 Nov;93(11):1496-500. doi: 10.1080/08035250410022314.

Human milk-derived fortifier versus bovine milk-derived fortifier for prevention of mortality and morbidity in preterm neonates.

Cochrane Database Syst Rev. 2019 Nov 7;2019(11):CD013145. doi: 10.1002/14651858.CD013145.pub2.

Highest concentration of breast-milk-derived exosomes in colostrum.

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Human breast milk exosomes attenuate intestinal damage.

Pediatr Surg Int. 2020 Feb;36(2):155-163. doi: 10.1007/s00383-019-04599-7. Epub 2019 Nov 12.

Human milk and necrotizing enterocolitis.

Semin Pediatr Surg. 2018 Feb;27(1):34-38. doi: 10.1053/j.sempedsurg.2017.11.007. Epub 2017 Nov 6.

Cytomegalovirus-associated necrotizing enterocolitis in a preterm twin after breastfeeding.

J Perinatol. 2004 Feb;24(2):124-6. doi: 10.1038/sj.jp.7211042.

Placebo Controlled Introduction of Prophylactic Supplementation of Probiotics to Decrease the Incidence of Necrotizing Enterocolitis at Dhulikhel Hospital in Nepal.

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引用本文的文献

Exosomes in Breast Milk: Their Impact on the Intestinal Microbiota of the Newborn and Therapeutic Perspectives for High-Risk Neonates.

Int J Mol Sci. 2025 Apr 5;26(7):3421. doi: 10.3390/ijms26073421.

Extracellular vesicles and preterm infant diseases.

Front Pediatr. 2025 Feb 17;13:1550115. doi: 10.3389/fped.2025.1550115. eCollection 2025.

Human milk extracellular vesicles modulate inflammation and cell survival in intestinal and immune cells.

Pediatr Res. 2024 Nov 28. doi: 10.1038/s41390-024-03757-5.

Potential therapeutic effects of milk-derived exosomes on intestinal diseases.

J Nanobiotechnology. 2023 Dec 20;21(1):496. doi: 10.1186/s12951-023-02176-8.

Antibiotic resistance and host immune system-induced metal bactericidal control are key factors for microbial persistence in the developing human preterm infant gut microbiome.

Front Microbiol. 2022 Nov 21;13:958638. doi: 10.3389/fmicb.2022.958638. eCollection 2022.

Beneficial Effects of Bovine Milk Exosomes in Metabolic Interorgan Cross-Talk.

Nutrients. 2022 Mar 30;14(7):1442. doi: 10.3390/nu14071442.

lncRNA is consistently detected in breastmilk exosomes and its expression is downregulated in mothers of preterm infants.

Int J Mol Med. 2021 Dec;48(6). doi: 10.3892/ijmm.2021.5049. Epub 2021 Oct 15.

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Human breast milk exosomes may protect against necrotizing enterocolitis in preterm infants.

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