Tobing Maringan, Arabia Futiha, Hidayat Yudi, Mantilidewi Kemala
Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia.
Dr. Hasan Sadikin Central General Hospital, Bandung, West Java, Indonesia.
Int J Gen Med. 2021 May 18;14:1899-1904. doi: 10.2147/IJGM.S271635. eCollection 2021.
Fifteen to twenty percent of the patients with complete hydatidiform mole transform malignancy into gestational trophoblastic tumors. The marked proliferation of trophoblastic cells is one of the characteristics that determines high risk for the occurrence of post-hydatidiform mole malignancy. The objective of the study was to analyze the histopathologic feature of the marked proliferation of trophoblastic cells as a role in post-hydatidiform mole malignancy that can be used as a determinant of the risk of malignancy post-hydatidiform mole.
The method of the study was analytical observational with a case-control study design. The data were taken retrospectively from medical records of patients with a post-complete hydatidiform mole malignancy and patients who do not develop post-complete hydatidiform mole malignancy (n = 34). The study took place in the Department of Anatomical Pathology Laboratorium at Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
The results showed a highly significant difference with the histopathologic characteristics of marked trophoblastic cell proliferation in post-complete hydatidiform mole malignancy, reaching up to 73.5%. In contrast, the difference between those who do not develop malignancy was 11.8%. The odds ratio (OR) was 20.83, with an interpretation that patients with a complete hydatidiform mole with the histopathological feature of marked trophoblastic cell proliferation had a risk of developing into malignancy 20.83 times higher compared to cases without marked trophoblastic cell proliferation.
The conclusion of the study was there is a significant correlation between marked trophoblastic cell proliferation with the incidence of post-complete hydatidiform mole malignancy.
15%至20%的完全性葡萄胎患者会恶变为妊娠滋养细胞肿瘤。滋养层细胞的显著增殖是决定葡萄胎后恶变高风险的特征之一。本研究的目的是分析滋养层细胞显著增殖的组织病理学特征在葡萄胎后恶变中的作用，其可作为葡萄胎后恶变风险的决定因素。
本研究采用分析性观察研究，采用病例对照研究设计。数据回顾性取自完全性葡萄胎后恶变患者和未发生完全性葡萄胎后恶变患者的病历（n = 34）。研究在印度尼西亚万隆哈桑·萨迪金医院解剖病理实验室进行。
结果显示，完全性葡萄胎后恶变中滋养层细胞显著增殖的组织病理学特征存在高度显著差异，高达73.5%。相比之下，未发生恶变者的差异为11.8%。优势比（OR）为20.83，这意味着具有滋养层细胞显著增殖组织病理学特征的完全性葡萄胎患者发生恶变的风险是无滋养层细胞显著增殖病例的20.83倍。
本研究的结论是，滋养层细胞显著增殖与完全性葡萄胎后恶变的发生率之间存在显著相关性。
