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对头颈部鳞状细胞癌免疫微环境的进一步理解：对预后的影响

Further Understanding of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma: Implications for Prognosis.

作者信息

Denaro Nerina, Merlano Marco Carlo, Lo Nigro Cristiana

机构信息

Medical Oncology, S. Croce & Carle Teaching Hospital, Cuneo, Italy.

Central Laboratory, Galliera Hospital, Genoa, Italy.

出版信息

Cancer Manag Res. 2021 May 17;13:3973-3980. doi: 10.2147/CMAR.S277907. eCollection 2021.

DOI:10.2147/CMAR.S277907
PMID:34040438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8139676/
Abstract

PURPOSE

We aimed to review the literature on the tumor microenvironment as a key player in tumor growth and anti-cancer treatment responses in head and neck cancer.

PATIENTS AND METHODS

We reviewed the recent literature on this topic, using the following research words: "tumor microenvironment" and "head and neck cancer or neoplasm or head and neck squamous cell carcinoma" and "immune cells" and "stromal cells". A search was conducted on the PubMed website and reports from international meetings, presentations and abstracts.

RESULTS

The tumor microenvironment is a complex network in which myeloid cells, tumoral cells, growth factors and cytokines are involved in angiogenesis, the extracellular matrix and epithelial-to-mesenchymal transition.

CONCLUSION

Immune resistance and rapid tumor growth depend on immunosuppressive and pro-tumoral environments. Further investigations to classify and adequately treat patients with head and neck cancer are required.

摘要

目的

我们旨在综述有关肿瘤微环境作为头颈癌肿瘤生长和抗癌治疗反应关键因素的文献。

患者与方法

我们使用以下检索词综述了关于该主题的近期文献：“肿瘤微环境”、“头颈癌或肿瘤或头颈部鳞状细胞癌”、“免疫细胞”和“基质细胞”。在PubMed网站以及国际会议报告、演讲和摘要中进行了检索。

结果

肿瘤微环境是一个复杂的网络，其中髓样细胞、肿瘤细胞、生长因子和细胞因子参与血管生成、细胞外基质和上皮-间质转化。

结论

免疫抵抗和肿瘤快速生长取决于免疫抑制和促肿瘤环境。需要进一步开展研究以对头颈癌患者进行分类并给予充分治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/899b53f5fe43/CMAR-13-3973-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/4b0226e005b3/CMAR-13-3973-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/0638e4786de2/CMAR-13-3973-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/899b53f5fe43/CMAR-13-3973-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/4b0226e005b3/CMAR-13-3973-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/0638e4786de2/CMAR-13-3973-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e08/8139676/899b53f5fe43/CMAR-13-3973-g0003.jpg

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