McDonald Suzanne, Vieira Rute, Johnston Derek W
Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.
Health Psychol Behav Med. 2020 Jan 22;8(1):32-54. doi: 10.1080/21642850.2019.1711096.
: N-of-1 observational studies can be used to describe natural intra-individual changes in health-related behaviours or symptoms over time, to test behavioural theories and to develop highly personalised health interventions. To date, N-of-1 observational methods have been under-used in health psychology and behavioural medicine. One reason for this may be the perceived complexity of statistical analysis of N-of-1 data. This tutorial paper describes a 10-step procedure for the analysis of N-of-1 observational data using dynamic regression modelling in SPSS for researchers, students and clinicians who are new to this area. The 10-step procedure is illustrated using real data from an N-of-1 observational study exploring the relationship between pain and physical activity. The availability of a user-friendly and robust statistical technique for the analysis of N-of-1 data using SPSS may foster increased awareness, knowledge and skills and establish N-of-1 designs as a useful methodological tool in health psychology and behavioural medicine.
单病例观察性研究可用于描述与健康相关行为或症状随时间的个体内部自然变化，检验行为理论，并制定高度个性化的健康干预措施。迄今为止，单病例观察性方法在健康心理学和行为医学中未得到充分利用。其原因之一可能是认为单病例数据的统计分析很复杂。本教程文章为该领域的新手研究人员、学生和临床医生描述了一个使用SPSS中的动态回归模型分析单病例观察性数据的10步程序。使用来自一项探索疼痛与身体活动之间关系的单病例观察性研究的真实数据说明了这10步程序。使用SPSS分析单病例数据的用户友好且强大的统计技术的可用性可能会提高人们的认识、知识和技能，并将单病例设计确立为健康心理学和行为医学中一种有用的方法工具。
