Coutelier J P, Van Snick J
Unit of Experimental Medicine, Université Catholique de Louvain, Bruxelles, Belgium.
J Gen Virol. 1988 Aug;69 ( Pt 8):2097-100. doi: 10.1099/0022-1317-69-8-2097.
Monoclonal antibodies directed against VP3, the envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV), were found to neutralize a large proportion of the virus population. This effect of monoclonal anti-VP3 antibodies was significantly increased by a murine monoclonal rheumatoid factor, indicating that the same antiviral antibodies can either neutralize or sensitize different fractions of the virus. This observation could be explained by heterogeneity in LDV particles, resulting in diverse responses to antibodies and therefore to the persistence of the virus in vivo.
针对乳酸脱氢酶升高病毒（LDV）包膜糖蛋白VP3的单克隆抗体被发现可中和大部分病毒群体。鼠源单克隆类风湿因子可显著增强单克隆抗VP3抗体的这种作用，这表明相同的抗病毒抗体可以中和或致敏不同部分的病毒。这一观察结果可以用LDV颗粒的异质性来解释，这种异质性导致对抗体产生不同反应，进而导致病毒在体内持续存在。
