利用转换突变体揭示免疫球蛋白G2a亚类在抗体介导的抗乳酸脱氢酶升高病毒诱导的脑脊髓灰质炎保护中的功效增强。
Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants.
作者信息
Markine-Goriaynoff Dominique, Coutelier Jean-Paul
机构信息
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Brussels, Belgium.
出版信息
J Virol. 2002 Jan;76(1):432-5. doi: 10.1128/jvi.76.1.432-435.2002.
Abstract
Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.
摘要
免疫球蛋白G1（IgG1）、IgG2a和IgG2b转换变体源自一种针对乳酸脱氢酶升高病毒（LDV）的VP3包膜糖蛋白的IgG3单克隆抗体。在这四种抗体中，IgG2a比其他亚类更能延缓LDV诱导的脑脊髓灰质炎的发病和进展。这表明，在许多由活病毒引发的IgG抗体反应中观察到的IgG2a优势，至少在某些情况下，可能对应于为受感染宿主选择的最佳保护。
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