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1
Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants.利用转换突变体揭示免疫球蛋白G2a亚类在抗体介导的抗乳酸脱氢酶升高病毒诱导的脑脊髓灰质炎保护中的功效增强。
J Virol. 2002 Jan;76(1):432-5. doi: 10.1128/jvi.76.1.432-435.2002.
2
The murine antibody response to lactate dehydrogenase-elevating virus.小鼠对乳酸脱氢酶升高病毒的抗体反应。
J Gen Virol. 1986 Jun;67 ( Pt 6):1099-108. doi: 10.1099/0022-1317-67-6-1099.
3
Characteristics of monoclonal antibodies to the lactate dehydrogenase-elevating virus.抗乳酸脱氢酶升高病毒单克隆抗体的特性
Intervirology. 1987;27(1):53-60. doi: 10.1159/000149715.
4
IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies.IgG亚型与抗单纯疱疹病毒糖蛋白D单克隆抗体的被动保护效率和效应功能相关。
J Infect Dis. 1995 Oct;172(4):1108-11. doi: 10.1093/infdis/172.4.1108.
5
Neutralization and sensitization of lactate dehydrogenase-elevating virus with monoclonal antibodies.用单克隆抗体中和及致敏乳酸脱氢酶升高病毒
J Gen Virol. 1988 Aug;69 ( Pt 8):2097-100. doi: 10.1099/0022-1317-69-8-2097.
6
Detection of the binding of IgG2a and IgG2b on the surface of macrophages from mice chronically infected with lactic dehydrogenase virus.检测慢性感染乳酸脱氢酶病毒的小鼠巨噬细胞表面IgG2a和IgG2b的结合情况。
J Comp Pathol. 1992 Jul;107(1):35-40. doi: 10.1016/0021-9975(92)90093-a.
7
Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus.小鼠在感染乳酸脱氢酶升高病毒及用灭活病毒免疫期间对该病毒的抗体反应。
Virus Res. 1986 Sep;5(4):357-75. doi: 10.1016/0168-1702(86)90029-8.
8
Neonatal infection of mice with lactate dehydrogenase-elevating virus results in suppression of humoral antiviral immune response but does not alter the course of viraemia or the polyclonal activation of B cells and immune complex formation.新生小鼠感染乳酸脱氢酶升高病毒会导致体液抗病毒免疫反应受到抑制，但不会改变病毒血症的进程，也不会改变B细胞的多克隆激活及免疫复合物的形成。
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9
Changes in the specificity of antibodies in mice infected with lactate dehydrogenase-elevating virus.感染乳酸脱氢酶升高病毒的小鼠体内抗体特异性的变化。
Scand J Immunol. 1997 Aug;46(2):168-74. doi: 10.1046/j.1365-3083.1997.d01-107.x.
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Autoimmunity induced by lactate dehydrogenase-elevating virus: monoclonal autoantibodies against Golgi antigens and other subcellular elements.乳酸脱氢酶升高病毒诱导的自身免疫：针对高尔基体抗原和其他亚细胞成分的单克隆自身抗体。
Autoimmunity. 1989;2(3):201-11. doi: 10.3109/08916938909014684.

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NADPH oxidase exerts a B cell-intrinsic contribution to lupus risk by modulating endosomal TLR signals.NADPH 氧化酶通过调节内体 TLR 信号发挥 B 细胞内在的狼疮风险贡献。
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本文引用的文献

1
IFN-gamma-independent IgG2a production in mice infected with viruses and parasites.感染病毒和寄生虫的小鼠中不依赖干扰素-γ的IgG2a产生
Int Immunol. 2000 Feb;12(2):223-30. doi: 10.1093/intimm/12.2.223.
2
Neuropathogenicity and sensitivity to antibody neutralization of lactate dehydrogenase-elevating virus are determined by polylactosaminoglycan chains on the primary envelope glycoprotein.乳酸脱氢酶升高病毒的神经致病性和对抗体中和的敏感性由主要包膜糖蛋白上的聚乳糖胺聚糖链决定。
Virology. 2000 Jan 5;266(1):88-98. doi: 10.1006/viro.1999.0050.
3
The role of antibody concentration and avidity in antiviral protection.抗体浓度和亲和力在抗病毒保护中的作用。
Science. 1997 Jun 27;276(5321):2024-7. doi: 10.1126/science.276.5321.2024.
4
Coexistence in lactate dehydrogenase-elevating virus pools of variants that differ in neuropathogenicity and ability to establish a persistent infection.乳酸脱氢酶升高病毒库中神经致病性和建立持续感染能力不同的变体的共存。
J Virol. 1997 Apr;71(4):2913-20. doi: 10.1128/JVI.71.4.2913-2920.1997.
5
The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in mice.抗黄热病毒NS1抗体的Fc部分是小鼠抵抗黄热脑炎的保护决定因素。
Virology. 1993 Jan;192(1):132-41. doi: 10.1006/viro.1993.1015.
6
A simple technique for the rapid enrichment of class and subclass hybridoma switch variants. A 1000-fold enrichment in half the time, for half the cost.一种快速富集类别和亚类杂交瘤转换变体的简单技术。在一半时间内实现1000倍富集，成本降低一半。
J Immunol Methods. 1993 Oct 15;165(2):217-24. doi: 10.1016/0022-1759(93)90347-a.
7
Difference in neutralization between lactate dehydrogenase-elevating virus isolated from acutely and chronically infected mice.从急性和慢性感染小鼠中分离出的乳酸脱氢酶升高病毒之间的中和差异。
J Gen Virol. 1994 May;75 ( Pt 5):1173-6. doi: 10.1099/0022-1317-75-5-1173.
8
Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice.免疫球蛋白G（IgG）而非IgM或IgA同种型的病毒中和抗体可治愈严重联合免疫缺陷（SCID）小鼠的流感病毒肺炎。
J Virol. 1995 Apr;69(4):2075-81. doi: 10.1128/JVI.69.4.2075-2081.1995.
9
Roles of immunoglobulin valency and the heavy-chain constant domain in antibody-mediated downregulation of Sindbis virus replication in persistently infected neurons.免疫球蛋白价态和重链恒定结构域在抗体介导的持续性感染神经元中辛德毕斯病毒复制下调中的作用。
J Virol. 1995 Mar;69(3):1990-3. doi: 10.1128/JVI.69.3.1990-1993.1995.
10
IgG subtype is correlated with efficiency of passive protection and effector function of anti-herpes simplex virus glycoprotein D monoclonal antibodies.IgG亚型与抗单纯疱疹病毒糖蛋白D单克隆抗体的被动保护效率和效应功能相关。
J Infect Dis. 1995 Oct;172(4):1108-11. doi: 10.1093/infdis/172.4.1108.

利用转换突变体揭示免疫球蛋白G2a亚类在抗体介导的抗乳酸脱氢酶升高病毒诱导的脑脊髓灰质炎保护中的功效增强。

Increased efficacy of the immunoglobulin G2a subclass in antibody-mediated protection against lactate dehydrogenase-elevating virus-induced polioencephalomyelitis revealed with switch mutants.

作者信息

Markine-Goriaynoff Dominique, Coutelier Jean-Paul

机构信息

Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Brussels, Belgium.

出版信息

J Virol. 2002 Jan;76(1):432-5. doi: 10.1128/jvi.76.1.432-435.2002.

DOI:10.1128/jvi.76.1.432-435.2002
PMID:11739710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC135718/
Abstract

Immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants were derived from an IgG3 monoclonal antibody directed against the VP3 envelope glycoprotein of lactate dehydrogenase-elevating virus (LDV). Among the four antibodies, IgG2a delayed the onset and progression of LDV-induced polioencephalomyelitis more than did the other subclasses. This suggests that the IgG2a predominance observed in many IgG antibody responses elicited by live viruses could, at least under some circumstances, correspond to the selection of the best protection for the infected host.

摘要

免疫球蛋白G1（IgG1）、IgG2a和IgG2b转换变体源自一种针对乳酸脱氢酶升高病毒（LDV）的VP3包膜糖蛋白的IgG3单克隆抗体。在这四种抗体中，IgG2a比其他亚类更能延缓LDV诱导的脑脊髓灰质炎的发病和进展。这表明，在许多由活病毒引发的IgG抗体反应中观察到的IgG2a优势，至少在某些情况下，可能对应于为受感染宿主选择的最佳保护。