Rocco Joseph M, Rosen Lindsey B, Hong Gloria H, Treat Jennifer, Kreuzburg Samantha, Holland Steven M, Zerbe Christa S
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Transl Autoimmun. 2021 May 4;4:100102. doi: 10.1016/j.jtauto.2021.100102. eCollection 2021.
Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production of autoantibodies. We combined bortezomib with rituximab to reduce autoantibodies leading to clinical and radiographic improvement in infection.
干扰素-γ自身抗体增加播散性非结核分枝杆菌感染的风险。在抗生素治疗中加用利妥昔单抗可加速并改善治疗效果，但由于自身抗体持续产生，可能会出现难治性感染。我们将硼替佐米与利妥昔单抗联合使用以减少自身抗体，从而使感染在临床和影像学方面得到改善。
