Imran Eisha, Moeen Faisal, Abbas Beenish, Yaqoob Bakhtawar, Wajahat Mehreen, Khan Quratulain, Khurshid Zohaib
Department of Dental Materials, Islamic International Dental College, Riphah University, Islamabad, Pakistan.
Department of Pediatric Dentistry, College of Dentistry, Foundation University, Islamabad, Pakistan.
Eur J Dent. 2021 Oct;15(4):660-668. doi: 10.1055/s-0041-1727553. Epub 2021 May 26.
This study aimed to evaluate and compare various commercially available local anesthetic solutions.
A total of 150 commercially available local anesthetic cartridges of similar composition (2% lidocaine with epinephrine 1:100,000) were randomly collected and divided into 3 groups. The designations of groups were selected from their product names such that each group consisted of 60 cartridges. Group S (Septodont, France) Group M (Medicaine, Korea) and Group H (HD-Caine, Pakistan). The samples were divided into five sub-groups, each consisting of 10 cartridges from each group to investigate each parameter.
The acquired data was statistically analyzed and compared (using SPSS version 12). Compositional analysis revealed a non-significant (P>0.05) difference when the three Groups were compared with standard lidocaine and epinephrine solutions. The mean pH values of samples from group S, M, and H respectively fell within the range of pH values of commercially available solutions. Non-significant difference in EPT values of Group S and H was found when efficacy was compared ( = 0.3), however a significant difference ( < 0.01) was observed in contrast to Group M. Anti-bacterial activity was observed in all the group and a non-significant difference in cell viability values of Group S and M was found ( = 0.6), while the difference was significant in comparison to Group H.
Within the limitations of these investigations, it appears that the properties of different manufacturers fall within the recommended ranges as mentioned in literature and do not appear to be statistically different in the variables we have tested.
本研究旨在评估和比较各种市售局部麻醉剂溶液。
随机收集150支成分相似的市售局部麻醉剂药筒（2%利多卡因加1:100,000肾上腺素），并分为3组。根据产品名称对组进行命名，每组由60支药筒组成。S组（法国Septodont公司）、M组（韩国Medicaine公司）和H组（巴基斯坦HD-Caine公司）。将样本分为五个亚组，每组由来自每组的10支药筒组成，以研究每个参数。
对获得的数据进行统计分析和比较（使用SPSS 12版）。成分分析显示，将三组与标准利多卡因和肾上腺素溶液进行比较时，差异无统计学意义（P>0.05）。S组、M组和H组样本的平均pH值分别落在市售溶液的pH值范围内。比较疗效时，S组和H组的EPT值差异无统计学意义（ = 0.3），但与M组相比差异有统计学意义（ < 0.01）。在所有组中均观察到抗菌活性，S组和M组的细胞活力值差异无统计学意义（ = 0.6），但与H组相比差异有统计学意义。
在这些研究的局限性范围内，不同制造商生产的产品特性似乎落在文献中推荐的范围内，并且在我们测试的变量中似乎没有统计学差异。
