Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Eat Disord. 2021 Sep;54(9):1563-1574. doi: 10.1002/eat.23561. Epub 2021 May 27.
In the present systematic review and meta-analysis study, we aimed to review studies that assessed the prevalence and risk of eating disorders (EDs) in patients with celiac disease (CD) and vice-versa.
We conducted a systematic search in PubMed, Embase, Scopus, and Web of Science for studies that assessed the prevalence and risk of AN in patients with CD and vice-versa. Joanna Briggs Institute tools were used for critical appraisal. The STATA software was used for the meta-analysis of the random-effect model.
In this study, 23 observational studies were included. The results of the meta-analysis indicated that the pooled prevalence of EDs and bulimia nervosa in patients with CD was 8.88% [95% CI: 6.4, 11.7] and 7.26% [95% CI: 0.23, 21.57], respectively. Moreover, the risk of anorexia nervosa in patients with CD was significantly higher than in the healthy population (relative risk [RR]: 1.48 [95% CI: 1.32, 1.64]). The rates of CD in patients with AN and EDs were 0.96% [95% CI: 0.15, 2.31] and 0.90% [95% CI: 0.56, 1.31], respectively. Moreover, the overall risk of CD in patients with AN was significantly higher compared with healthy adults (RR: 2.35 [95% CI: 1.27-3.44]).
The result of the present meta-analysis showed the high prevalence of EDs in patients with CD. Moreover, there was a significant bidirectional association between CD and EDs.
在本系统评价和荟萃分析研究中，我们旨在回顾评估乳糜泻（CD）患者和反之患饮食障碍（EDs）的患病率和风险的研究。
我们在 PubMed、Embase、Scopus 和 Web of Science 中进行了系统搜索，以评估 CD 患者和反之患 AN 的患病率和风险的研究。我们使用 Joanna Briggs Institute 工具进行批判性评估。STATA 软件用于随机效应模型的荟萃分析。
在这项研究中，纳入了 23 项观察性研究。荟萃分析的结果表明，CD 患者 EDs 和神经性贪食症的总患病率分别为 8.88%[95%CI：6.4，11.7]和 7.26%[95%CI：0.23，21.57]。此外，CD 患者患神经性厌食症的风险明显高于健康人群（相对风险[RR]：1.48[95%CI：1.32，1.64]）。CD 在 AN 和 EDs 患者中的发生率分别为 0.96%[95%CI：0.15，2.31]和 0.90%[95%CI：0.56，1.31]。此外，与健康成年人相比，AN 患者的 CD 总体风险明显更高（RR：2.35[95%CI：1.27-3.44]）。
本荟萃分析的结果表明，CD 患者 EDs 的患病率较高。此外，CD 和 EDs 之间存在显著的双向关联。
