Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt.
J Cosmet Dermatol. 2022 Apr;21(4):1625-1628. doi: 10.1111/jocd.14252. Epub 2021 Jun 21.
Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues, and its etiology and pathogenesis are unclear. Cytokines have a significant role in the beginning, the maintenance of inflammatory and intercellular crosstalk.
We assessed serum levels of neutrophil activation marker (calprotectin) in patients with cutaneous lichen planus with different subtypes and made a comparison with healthy individuals.
Peripheral blood samples of 30 cases with lichen planus were compared with 30 healthy individuals. Serum samples were prepared from LP patients, using a commercial ELISA kit, and calprotectin level was measured in each serum sample.
The serum level of calprotectin was significantly raised in LP cases compared with control (141.34 ± 17.47 ng/ml versus 40.03 ± 1.54 ng/ml respectively; p < 0.001). No correlation was recorded among of serum of calprotectin and patients' ages, sex, disease period, and the existence or strength of pruritus. But a strong positive correlation was present between the coexistence of oral lesions and the number of locations.
Calprotectin can be used as a marker of Lichen planus severity and progression. Calprotectin may play a role in the pathogenesis of LP.
扁平苔藓病是一种慢性炎症性黏膜和皮肤组织疾病，其病因和发病机制尚不清楚。细胞因子在炎症的开始、维持和细胞间的相互作用中起着重要作用。
我们评估了不同亚型皮肤扁平苔藓患者的中性粒细胞活化标志物（钙卫蛋白）的血清水平，并与健康个体进行了比较。
将 30 例扁平苔藓患者的外周血样本与 30 例健康个体进行比较。使用商业 ELISA 试剂盒从 LP 患者中制备血清样本，并测量每个血清样本中的钙卫蛋白水平。
与对照组相比，LP 患者的血清钙卫蛋白水平显著升高（分别为 141.34±17.47ng/ml 和 40.03±1.54ng/ml；p<0.001）。血清钙卫蛋白与患者年龄、性别、疾病病程以及瘙痒的存在或强度之间无相关性。但口腔病变的存在和病变部位的数量之间存在强烈的正相关。
钙卫蛋白可作为扁平苔藓严重程度和进展的标志物。钙卫蛋白可能在 LP 的发病机制中起作用。
