Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Department of Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
J Cosmet Dermatol. 2021 Sep;20(9):2940-2944. doi: 10.1111/jocd.13926. Epub 2021 Jan 9.
Lichen planus is a common chronic cutaneous inflammatory disease. Recent advances evidenced that angiogenesis is tightly connected to it. More recently, the endothelial specific growth factor angiopoietin-2 has been clarified to interact with vascular endothelial growth factor. Angiopoietin-2 level has not been investigated in lichen planus.
To evaluate serum level of angiopoietin-2 in cutaneous and oral lichen planus.
Ninety patients were investigated, 45 patients with lichen planus. In addition to forty-five healthy control, the activity of the disease was estimated at the time of examination. The serum level of angiopoietin-2 had been estimated by enzyme-linked immunosorbent assay. The relationships between angiopoietin-2 serum level and disease severity, type of lichen, and visual analogue scale score (VAS) were determined.
The serum levels of angiopoietin-2 were substantially higher in patients with both cutaneous and oral lesions than patients with cutaneous lichen planus only (P < .001).
Serum angiopoietin-2 is elevated in patients compared with normal subjects and is correlated with the presence of oral lesions and disease severity, that reflects its role in angiogenesis and inflammation, and angiopoietin-2 serum level could be a potential marker for monitoring the oral lichen to identify possible malignant transformation.
扁平苔藓是一种常见的慢性皮肤炎症性疾病。最近的研究进展表明，血管生成与该病密切相关。最近，内皮细胞特异性生长因子血管生成素-2 已被证实与血管内皮生长因子相互作用。扁平苔藓中尚未研究血管生成素-2 的水平。
评估皮肤和口腔扁平苔藓患者的血清血管生成素-2 水平。
共调查了 90 例患者，其中 45 例为扁平苔藓患者。除了 45 名健康对照者外，还在检查时评估了疾病的活动度。采用酶联免疫吸附试验法测定血管生成素-2 的血清水平。确定血管生成素-2 血清水平与疾病严重程度、扁平苔藓类型和视觉模拟评分（VAS）之间的关系。
与仅患有皮肤扁平苔藓的患者相比，患有皮肤和口腔病变的患者的血清血管生成素-2 水平明显升高（P<.001）。
与正常受试者相比，患者的血清血管生成素-2 升高，与口腔病变和疾病严重程度相关，反映了其在血管生成和炎症中的作用，血管生成素-2 血清水平可能是监测口腔扁平苔藓以识别可能发生恶性转化的潜在标志物。
