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基因组测序鉴定出一株来自孟加拉国达卡的、具有大量突变的新冠病毒B.1.1.7谱系毒株。

Genome Sequencing Identified a SARS-CoV-2 Lineage B.1.1.7 Strain with a High Number of Mutations from Dhaka, Bangladesh.

作者信息

Mazumder Razib, Abdullah Ahmed, Hossain Mohammad Enayet, Rahman M Mahfuzur, Bin Manjur Omar Hamza, Rahman Mustafizur, Mondal Dinesh

机构信息

Genomics Center, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

Virology Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

出版信息

Microbiol Resour Announc. 2021 May 27;10(21):e0034521. doi: 10.1128/MRA.00345-21.

DOI:10.1128/MRA.00345-21
PMID:34042471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8201627/
Abstract

We report a coding-complete genome sequence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain SARS-CoV-2/BGD/GC001, isolated from a Bangladeshi patient with respiratory symptoms. Phylogenetic analysis assigned this strain to lineage B.1.1.7, which presented a total of 36 mutations in the spike and other genomic regions compared to strain Wuhan Hu-1 (GenBank accession number NC_045512.2).

摘要

我们报告了从一名有呼吸道症状的孟加拉国患者身上分离出的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）毒株SARS-CoV-2/BGD/GC001的完整编码基因组序列。系统发育分析将该毒株归类为B.1.1.7谱系，与武汉Hu-1毒株（GenBank登录号NC_045512.2）相比，该毒株在刺突蛋白和其他基因组区域共有36个突变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f031/8201627/cc134aa205cb/mra.00345-21-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f031/8201627/cc134aa205cb/mra.00345-21-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f031/8201627/cc134aa205cb/mra.00345-21-f0001.jpg

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