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从孟加拉国新冠肺炎患者中检测到的9株新冠病毒编码完整的基因组序列及突变图谱

Coding-Complete Genome Sequences and Mutation Profiles of Nine SARS-CoV-2 Strains Detected from COVID-19 Patients in Bangladesh.

作者信息

Adnan Nihad, Khondoker Mohib Ullah, Rahman M Shaminur, Ahmed M Firoz, Sharmin Shahana, Sharif Nadim, Azmuda Nafisa, Akter Salma, Nahar Shamsun, Mou Taslin Jahan, Marzan Mahfuza, Liza Syeda Moriam, Jahan Nowshin, Ali Tamanna, Khandker Shahad Saif, Jamiruddin Maha, Chaity Mousumi Akter, Caller Laura Grace, Haq M Ahsanul, Jamiruddin Mohd Raeed

机构信息

Department of Microbiology, Jahangirnagar University, Savar, Dhaka, Bangladesh.

Gonoshasthaya-RNA Molecular Diagnostic and Research Center, Dhanmondi, Dhaka, Bangladesh.

出版信息

Microbiol Resour Announc. 2021 Mar 11;10(10):e00124-21. doi: 10.1128/MRA.00124-21.

DOI:10.1128/MRA.00124-21
PMID:33707329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7953292/
Abstract

Here, we report the coding-complete genome sequences of nine clinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and their mutations. The samples were collected from nine Bangladeshi coronavirus disease 2019 (COVID-19) patients. We have identified the E484K escape mutation and the S359T mutation within the spike protein coding region of the sequenced genomes.

摘要

在此，我们报告了9种临床严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体及其突变的完整编码基因组序列。样本取自9名孟加拉国2019冠状病毒病（COVID-19）患者。我们在测序基因组的刺突蛋白编码区域内鉴定出了E484K逃逸突变和S359T突变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8606/7953292/66b037901c90/MRA.00124-21-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8606/7953292/66b037901c90/MRA.00124-21-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8606/7953292/66b037901c90/MRA.00124-21-f0001.jpg

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