Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ordu University, Turkey.
Dent Med Probl. 2021 Apr-Jun;58(2):229-235. doi: 10.17219/dmp/132515.
This review aimed to assess the current evidence on the diagnostic potential of saliva regarding the detection of coronavirus disease 2019 (COVID-19). The literature published until May 24, 2020 was searched in the Web of Science, PubMed and Google Scholar databases with the keywords "COVID-19", "SARS-CoV-2", "2019-nCoV", "oral fluid", "saliva", and "diagnosis", individually and in combination, and 11 studies that explored the efficacy of saliva in the diagnosis of COVID-19 in different patient groups were found. Together, these studies suggest that saliva is a safe and reliable tool for the diagnosis of COVID-19. Further, saliva offers enhanced safety as well as logistical and economic benefits as compared to the current methods used to diagnose COVID-19. However, there is still limited evidence in the literature to make a definitive, clinically appropriate decision. The ideal specimen for the detection of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still an issue under investigation. Thus, new studies with large sample sets for the validation of easy, safe and reliable methods applicable for large-scale testing are immediately required.
本综述旨在评估唾液在检测 2019 冠状病毒病（COVID-19）方面的诊断潜力的现有证据。使用“COVID-19”、“SARS-CoV-2”、“2019-nCoV”、“口腔液”、“唾液”和“诊断”等关键词，分别和组合在 Web of Science、PubMed 和 Google Scholar 数据库中搜索截至 2020 年 5 月 24 日的文献，共找到 11 项研究，这些研究探讨了唾液在不同患者群体中诊断 COVID-19 的效果。这些研究共同表明，唾液是 COVID-19 诊断的一种安全可靠的工具。此外，与目前用于诊断 COVID-19 的方法相比，唾液具有更高的安全性和后勤及经济效益。然而，目前文献中仍然缺乏明确的、临床适用的决策证据。用于检测急性呼吸综合征冠状病毒 2（SARS-CoV-2）的理想标本仍然是一个正在研究的问题。因此，需要立即开展新的研究，这些研究应具有较大的样本量，以验证适用于大规模检测的简便、安全和可靠的方法。
