Yao Y M, Zhang H, Tong Y L
Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
Department of Burns and Plastic Surgery, the 924th Hospital of PLA, Guilin 541002, China.
Zhonghua Shao Shang Za Zhi. 2021 May 20;37(5):404-409. doi: 10.3760/cma.j.cn501120-20200703-00337.
Burn patients with large area of skin defect are prone to cause wound infection, severe fluid loss, and hypermetabolism, etc, which lead to sequential dysfunction of multiple systems and easily induce severe systemic infections and sepsis. At present, sepsis has been the leading causes of death in severe burn patients, and its early diagnosis and timely treatment are critical for successful treatment of patients. As burn sepsis has unique pathophysiological characteristics, the diagnostic criteria for general sepsis lack specificity for burn sepsis. Therefore, to understand the pathogenesis of burn will help deepen the understanding of the diagnostic system and interventional way of burn sepsis, thus developing more precise and intelligent therapeutic strategy.
大面积皮肤缺损的烧伤患者容易引发伤口感染、严重体液丢失和高代谢等问题，进而导致多系统的序贯性功能障碍，并易诱发严重的全身感染和脓毒症。目前，脓毒症一直是重度烧伤患者死亡的主要原因，其早期诊断和及时治疗对于患者的成功救治至关重要。由于烧伤脓毒症具有独特的病理生理特征，一般脓毒症的诊断标准对烧伤脓毒症缺乏特异性。因此，了解烧伤的发病机制将有助于加深对烧伤脓毒症诊断体系和干预方式的理解，从而制定更精准、智能的治疗策略。
