He T, Liu W, Shen Z A
Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Oct 20;39(10):985-988. doi: 10.3760/cma.j.cn501225-20221120-00498.
Sepsis is a severe life-threatening syndrome characterized by an abnormal host response to infection that can rapidly evolve into septic shock and multiple organ failure. Treatment of sepsis depends on early identification and diagnosis as well as adequate and timely anti-infection and multi-organ functional support. In recent years, pancreatic stone protein has been widely studied as a new biomarker for sepsis. Existing evidence shows that compared with the commonly used inflammatory markers in clinical practice, pancreatic stone protein has higher sensitivity and specificity in the diagnosis of sepsis. It enables the early diagnosis of sepsis and assessment of the severity of septic patients to a certain extent. This article reviews the characteristics, biological functions, diagnostic features, and clinical application of pancreatic stone protein.
脓毒症是一种严重的、危及生命的综合征，其特征是宿主对感染的异常反应，可迅速发展为感染性休克和多器官功能衰竭。脓毒症的治疗取决于早期识别和诊断以及充分及时的抗感染和多器官功能支持。近年来，胰石蛋白作为脓毒症的一种新生物标志物受到广泛研究。现有证据表明，与临床实践中常用的炎症标志物相比，胰石蛋白在脓毒症诊断中具有更高的敏感性和特异性。它在一定程度上能够实现脓毒症的早期诊断和对脓毒症患者严重程度的评估。本文综述了胰石蛋白的特征、生物学功能、诊断特点及临床应用。
