Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
The Second Clinical Medicine School, Wenzhou Medical University, Wenzhou, Zhejiang, China.
J Int Med Res. 2021 May;49(5):3000605211016137. doi: 10.1177/03000605211016137.
This study aimed to investigate the feasibility and reliability of pulse oximetry combined with cardiac auscultation in screening neonatal congenital heart disease (CHD).
This was a retrospective, observational, screening study. All newborns included in the study were at the Second Affiliated Hospital of Wenzhou Medical University from July 2019 to January 2020. Primary screening of CHD was conducted by pulse oximetry combined with cardiac auscultation assays. Indices, including sensitivity, specificity, the positive/negative predictive value, the positive/negative likelihood ratio, and the diagnostic odds ratio, were calculated. The area under the relative operating characteristic curve of the subjects was measured.
A total of 3327 neonates were enrolled, among whom 139 were diagnosed with CHD and the incidence of CHD was 4.2%. The sensitivity, specificity, diagnostic odds ratio, and area under the relative operating characteristic curve of pulse oximetry combined with cardiac auscultation were 89.9%, 94.7%, 169.0, and 0.923, respectively.
Pulse oximetry combined with cardiac auscultation is a novel screening method with acceptable accuracy and feasibility for neonatal CHD. This combination method is worth promoting widely.
本研究旨在探讨脉搏血氧仪联合心脏听诊用于筛查新生儿先天性心脏病（CHD）的可行性和可靠性。
这是一项回顾性、观察性的筛查研究。本研究纳入的所有新生儿均来自 2019 年 7 月至 2020 年 1 月温州医科大学附属第二医院。采用脉搏血氧仪联合心脏听诊法对 CHD 进行初步筛查。计算各项指标的敏感度、特异度、阳性/阴性预测值、阳性/阴性似然比和诊断优势比，并测量受试者的相对工作特征曲线下面积。
共纳入 3327 例新生儿，其中 139 例诊断为 CHD，CHD 的发病率为 4.2%。脉搏血氧仪联合心脏听诊的敏感度、特异度、诊断优势比和相对工作特征曲线下面积分别为 89.9%、94.7%、169.0 和 0.923。
脉搏血氧仪联合心脏听诊是一种新型的新生儿 CHD 筛查方法，具有可接受的准确性和可行性。该联合方法值得广泛推广。
