甘油三酯葡萄糖指数与中国人群颈动脉粥样硬化发病风险：一项前瞻性队列研究。
Triglyceride glucose index and carotid atherosclerosis incidence in the Chinese population: A prospective cohort study.
机构信息
Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Department of Public Health, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
出版信息
Nutr Metab Cardiovasc Dis. 2021 Jun 30;31(7):2042-2050. doi: 10.1016/j.numecd.2021.03.027. Epub 2021 Apr 20.
BACKGROUND AND AIMS
The association of the triglyceride glucose (TyG) index with carotid atherosclerosis has not been reported in longitudinal studies. The present study aimed to investigate whether the TyG index increases the risk of carotid atherosclerosis incidence.
METHODS AND RESULTS
This study included data from the Beijing Health Management Cohort (BHMC; n = 6955) and the Beijing Physical Examination Cohort (BPEC; n = 8473). Participants without a history of carotid atherosclerosis who underwent health examination in 2011 or 2012 were annually followed until 2019. The TyG index was denoted as ln [triglycerides (mmol/L)∗fasting glucose (mmol/L)/2]. During a median follow-up of 5.02 years and 5.36 years, 1441 individuals in the BHMC group and 2181 individuals in the BPEC group developed carotid plaque, respectively. The adjusted hazard ratios (HRs) of the continuous TyG index were 1.253 (95% CI, 1.044 to 1.505) and 1.252 (95% CI, 1.091 to 1.437) for the BHMC and BPEC groups, respectively. Individuals in the highest quartile of the TyG index were associated with an increased risk of carotid plaque compared with those in the lowest quartile (BHMC: HR, 1.366; 95% CI, 1.101 to 1.695, P for trend = 0.010; BPEC: HR, 1.379; 95% CI, 1.196 to 1.591, P for trend = 0.013).
CONCLUSION
These findings suggested that a higher TyG index increases the risk of carotid atherosclerosis incidence in the general population.
背景和目的
甘油三酯-葡萄糖（TyG）指数与颈动脉粥样硬化的相关性尚未在纵向研究中报道。本研究旨在探讨 TyG 指数是否会增加颈动脉粥样硬化发生的风险。
方法和结果
本研究纳入了北京健康管理队列（BHMC；n=6955）和北京体检队列（BPEC；n=8473）的数据。在 2011 或 2012 年进行健康检查且无颈动脉粥样硬化病史的参与者，每年随访至 2019 年。TyG 指数表示为 ln[甘油三酯（mmol/L）×空腹血糖（mmol/L）/2]。在中位随访 5.02 年和 5.36 年后，BHMC 组分别有 1441 人和 BPEC 组有 2181 人发展为颈动脉斑块。BHMC 组和 BPEC 组 TyG 指数连续变量的调整后危险比（HR）分别为 1.253（95%CI，1.044 至 1.505）和 1.252（95%CI，1.091 至 1.437）。与 TyG 指数最低四分位的个体相比，TyG 指数最高四分位的个体发生颈动脉斑块的风险增加（BHMC：HR，1.366；95%CI，1.101 至 1.695，P 趋势=0.010；BPEC：HR，1.379；95%CI，1.196 至 1.591，P 趋势=0.013）。
结论
这些发现表明，较高的 TyG 指数会增加一般人群发生颈动脉粥样硬化的风险。
Zotero 插件