School of Basic Medicine, Qingdao University, Qingdao, China.
Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China.
Mol Cancer Ther. 2021 Aug;20(8):1359-1366. doi: 10.1158/1535-7163.MCT-21-0050. Epub 2021 May 27.
In view of the increasing number of malignant tumors worldwide and their high mortality, efforts are being made to find effective biomarkers for early detection and effective treatment measures of cancer. In recent years, the roles of platelets in tumors have attracted considerable attention. Although platelets do not have nuclei, they are rich in miRNAs, which are important molecules in platelet regulation of tumors. Platelet miRNA expression in tumor patients is abnormal and tumor-specific. Platelet miRNAs have higher accuracy and specificity than conventional tumor detection markers and circulating miRNAs in tumor diagnosis. Platelets enriched miRNAs are involved in the regulation of tumor proliferation, metastasis, tumor-related immunity, tumor-related thrombosis, and antitumor therapy. To understand the role of platelet miRNAs in tumors, this article reviews the biological functions of miRNAs in platelets and summarizes the regulatory roles of platelet miRNAs in tumors and the potential roles of platelet miRNAs in tumor diagnosis and treatment.
鉴于全球恶性肿瘤数量的增加及其高死亡率，人们正在努力寻找有效的生物标志物，以实现癌症的早期检测和有效治疗措施。近年来，血小板在肿瘤中的作用引起了广泛关注。尽管血小板没有细胞核，但它们富含 miRNA，miRNA 是血小板调节肿瘤的重要分子。肿瘤患者的血小板 miRNA 表达异常且具有肿瘤特异性。血小板 miRNA 在肿瘤诊断中的准确性和特异性均高于传统肿瘤检测标志物和循环 miRNA。富含血小板的 miRNA 参与了肿瘤增殖、转移、肿瘤相关免疫、肿瘤相关血栓形成和抗肿瘤治疗的调节。为了了解血小板 miRNA 在肿瘤中的作用，本文综述了 miRNA 在血小板中的生物学功能，并总结了血小板 miRNA 在肿瘤中的调控作用以及血小板 miRNA 在肿瘤诊断和治疗中的潜在作用。
