Wang Luchang, Zhang Kaijiong, Feng Jia, Wang Dongsheng, Liu Jinbo
Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Department of Clinical Laboratory, Chengdu Second People's Hospital, Chengdu, 610017, People's Republic of China.
Cancer Manag Res. 2023 Aug 11;15:811-821. doi: 10.2147/CMAR.S418574. eCollection 2023.
Breast cancer is the most common female cancer and the sixth leading cause of death, seriously affecting the quality of life of women. Platelets, one of the fragments derived from megakaryocytes, are being increasingly investigated by tumor researchers because of their anticoagulant function. According to relevant studies, platelets, as the key source of circulating angiogenesis-related factors, can regulate tumor angiogenesis and vascular integrity, and they can also affect the tumor microenvironment, thereby facilitating the proliferation and differentiation of tumor cells. By covering or transferring normal MHC I molecules to tumor cells, platelets can protect tumor cells from being killed by the immune system and facilitate tumor cell metastasis. However, details on the mechanisms involved have remained elusive. This paper reviews and analyzes studies of the role of platelets in tumorigenesis, tumor cell proliferation, tumor metastasis, and cancer treatment to provide readers with a better understanding of the relevant studies.
乳腺癌是最常见的女性癌症，也是第六大死因，严重影响女性的生活质量。血小板是巨核细胞衍生的碎片之一，由于其抗凝功能，越来越受到肿瘤研究人员的关注。根据相关研究，血小板作为循环血管生成相关因子的关键来源，可调节肿瘤血管生成和血管完整性，还可影响肿瘤微环境，从而促进肿瘤细胞的增殖和分化。通过将正常的MHC I分子覆盖或转移到肿瘤细胞上，血小板可保护肿瘤细胞不被免疫系统杀死，并促进肿瘤细胞转移。然而，其中涉及的机制细节仍不清楚。本文回顾并分析了血小板在肿瘤发生、肿瘤细胞增殖、肿瘤转移和癌症治疗中的作用的研究，以便让读者更好地了解相关研究。
