Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma, Omiya-ku, Saitama, 330-8503, Japan.
Sci Rep. 2021 May 27;11(1):11140. doi: 10.1038/s41598-021-90042-8.
Complications such as slow flow are frequently observed in percutaneous coronary intervention (PCI) with rotational atherectomy (RA). However, it remains unclear whether the high incidence of slow flow results in the high incidence of periprocedural myocardial infarction (PMI), reflecting real myocardial damage. The aim of this study was to compare the incidence of PMI between PCI with versus without RA using propensity score-matching. We included 1350 elective PCI cases, which were divided into the RA group (n = 203) and the non-RA group (n = 1147). After propensity score matching, the matched RA group (n = 190) and the matched non-RA group (n = 190) were generated. The primary interest was to compare the incidence of PMI between the matched RA and non-RA groups. Before propensity score matching, the incidence of slow flow and PMI was greater in the RA group than in the non-RA group. After matching, the incidence of slow flow was still greater in the matched RA group than in the matched non-RA group (16.8% vs. 9.5%, p = 0.048). However, the incidence of PMI was similar between the matched RA and matched non-RA group (7.4% vs. 5.3%, p = 0.528, standardized difference: 0.086). In conclusion, although use of RA was associated with greater risk of slow flow, use of RA was not associated with PMI after a propensity score-matched analysis. The fact that RA did not increase the risk of myocardial damage in complex lesions would have an impact on revascularization strategy for severely calcified coronary lesions.
经皮冠状动脉介入治疗(PCI)伴旋磨术(RA)时,常观察到慢血流等并发症。然而,尚不清楚慢血流发生率高是否导致围手术期心肌梗死(PMI)发生率高,反映真实的心肌损伤。本研究旨在采用倾向评分匹配比较 PCI 伴 RA 与不伴 RA 患者的 PMI 发生率。共纳入 1350 例择期 PCI 病例,分为 RA 组(n = 203)和非 RA 组(n = 1147)。经倾向评分匹配后,生成匹配的 RA 组(n = 190)和匹配的非 RA 组(n = 190)。主要关注比较匹配的 RA 和非 RA 组之间的 PMI 发生率。在倾向评分匹配前,RA 组的慢血流和 PMI 发生率均高于非 RA 组。匹配后,匹配的 RA 组的慢血流发生率仍高于匹配的非 RA 组(16.8%比 9.5%,p = 0.048)。然而,匹配的 RA 组和匹配的非 RA 组的 PMI 发生率相似(7.4%比 5.3%,p = 0.528,标准化差异:0.086)。总之,尽管 RA 的使用与慢血流风险增加相关,但在倾向评分匹配分析后,RA 的使用与 PMI 无关。RA 并未增加严重钙化冠状动脉病变血运重建策略中心肌损伤的风险这一事实,将会对其产生影响。