Kumar Amarjeet, Kumar Abhyuday, Kumar Ajeet, Kumar Neeraj, Sinha Chandni, Singh Veena
Department of Trauma and Emergency, All India Institute of Medical Sciences, Patna, Bihar, India.
Department of Anaesthesiology, All India Institute of Medical Sciences, Patna, Bihar, India.
Indian J Crit Care Med. 2021 Apr;25(4):463-464. doi: 10.5005/jp-journals-10071-23786.
Severe acute respiratory syndrome coronavirus 2 is the pathogen that causes coronavirus disease-2019 (COVID-19). Recent studies have shown that the "cytokine storm" (high concentration of proinflammatory cytokines) may contribute to the mortality of COVID-19. Repeated exposure to the virus can lead to a dose-dependent immune response that may be associated with more disease severity and higher mortality. Sudden deterioration/increased oxygen consumption after initial improvement may be due to multiple surges of cytokines storm within a short period, the possible cause may be due to multiple exposures within the incubation period. We hypothesize that multiple surges in cytokines storm in some patients may be due to multiple exposures of the same patient within the incubation period, sepsis, or other inflammatory lesions inside the body. In our cases, sepsis as a cause of cytokine storm was ruled out by doing the procalcitonin test, which was within the normal limit.
Kumar A, Kumar A, Kumar A, Kumar N, Sinha C, Singh V. Multiple Peaked Cytokine Storm: Is Multiple Exposures to the COVID-19 Virus a Possible Cause? Indian J Crit Care Med 2021;25(4):463-464.
严重急性呼吸综合征冠状病毒2是导致2019冠状病毒病（COVID-19）的病原体。最近的研究表明，“细胞因子风暴”（促炎细胞因子的高浓度）可能导致COVID-19的死亡率。反复接触该病毒可导致剂量依赖性免疫反应，这可能与更高的疾病严重程度和死亡率相关。初始改善后突然恶化/耗氧量增加可能是由于短期内细胞因子风暴的多次激增，可能的原因可能是在潜伏期内的多次接触。我们假设，一些患者中细胞因子风暴的多次激增可能是由于同一患者在潜伏期内的多次接触、脓毒症或体内其他炎症性病变。在我们的病例中，通过进行降钙素原检测排除了脓毒症作为细胞因子风暴的原因，该检测结果在正常范围内。
库马尔A、库马尔A、库马尔A、库马尔N、辛哈C、辛格V。多峰细胞因子风暴：多次接触COVID-19病毒是可能的原因吗？《印度重症监护医学杂志》2021年；25(4):463 - 464。
