Rangappa Pradeep
Department of Critical Care Medicine, Columbia Asia, Bengaluru, Karnataka, India.
Indian J Crit Care Med. 2021 Nov;25(11):1288-1291. doi: 10.5005/jp-journals-10071-24029.
COVID-19 has become a major pandemic in recent times. The exact pathophysiology and understanding of cytokine storm and immunomodulation are evolving. Various cytokines have been implicated in the pathophysiology of COVID-19. Immunosuppressant immunomodulators like steroids, canakinumab, anakinra, tocilizumab, sarilumab, baricitinib, ruxolitinib, bevacizumab, and itolizumab have been tried. Immunostimulant immunomodulators like interferons (IFNs) and Mycobacterium w (Mw) have also been repurposed. Considering the role of multiple cytokines implicated in COVID-19, molecules working on the majority of the targets, may hold a promising future prospect.
Rangappa P. Cytokine Storm and Immunomodulation in COVID-19. Indian J Crit Care Med 2021;25(11):1288-1291.
近期，新型冠状病毒肺炎（COVID-19）已成为一场重大的大流行病。细胞因子风暴和免疫调节的确切病理生理学及相关认识正在不断发展。多种细胞因子与COVID-19的病理生理学有关。已尝试使用免疫抑制剂免疫调节剂，如类固醇、卡那单抗、阿那白滞素、托珠单抗、沙瑞鲁单抗、巴瑞替尼、芦可替尼、贝伐单抗和依托珠单抗。免疫刺激剂免疫调节剂，如干扰素（IFN）和结核分枝杆菌w（Mw）也已被重新利用。考虑到多种细胞因子在COVID-19中的作用，作用于大多数靶点的分子可能具有广阔的未来前景。
兰加帕P。COVID-19中的细胞因子风暴和免疫调节。《印度重症监护医学杂志》2021年；25（11）：1288 - 1291。
