Ye Lingling, Wang Fen, Wu Hao, Yang Hui, Yang Yan, Ma Yajun, Xue Aili, Zhu Jing, Chen Meili, Wang Jinyan, Zhang Quan An
Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Onco Targets Ther. 2021 May 20;14:3335-3349. doi: 10.2147/OTT.S305098. eCollection 2021.
MicroRNAs (miRNAs) are small non-coding RNAs (18~25 nt in length) that act as master regulators of eukaryotic gene expression. They might play an oncogenic or tumor-suppressive role in multiple cancers. In recent decades, several studies have focused on the functions and mechanisms of miR-335 in cancer. The expression level of miR-335 in tissues and cells varies with cancer types, and miR-335 has been proposed as a potential biomarker for the prognosis of cancer. Besides, miR-335 may serve as an oncogene or tumor suppressor via regulating different targets or pathways in tumor initiation, development, and metastasis. Furthermore, miR-335 also influences tumor microenvironment and drug sensitivity. MiR-335 is regulated by various factors such as lncRNAs and microRNAs. In this review, we reveal the functions and targets of miR-335 in various cancers and its potential application as a possible biomarker in prognostic judgment and treatment of malignant tumors.
微小RNA（miRNA）是一类小的非编码RNA（长度为18至25个核苷酸），它们是真核基因表达的主要调节因子。它们可能在多种癌症中发挥致癌或抑癌作用。近几十年来，多项研究聚焦于miR-335在癌症中的功能和机制。miR-335在组织和细胞中的表达水平因癌症类型而异，并且miR-335已被提议作为癌症预后的潜在生物标志物。此外，miR-335可能通过在肿瘤发生、发展和转移过程中调节不同的靶点或通路而充当癌基因或肿瘤抑制因子。此外，miR-335还影响肿瘤微环境和药物敏感性。miR-335受多种因素调控，如长链非编码RNA和微小RNA。在本综述中，我们揭示了miR-335在各种癌症中的功能和靶点，以及其作为恶性肿瘤预后判断和治疗中可能的生物标志物的潜在应用。
