第三天和第五/六天胚胎质量对单个玻璃化冷冻胚胎移植周期生殖结局的影响。
Effect of Day 3 and Day 5/6 Embryo Quality on the Reproductive Outcomes in the Single Vitrified Embryo Transfer Cycles.
机构信息
Department of Assisted Reproduction, Shanghai Ninth People's Hospital, School of Medicine, JiaoTong University, Shanghai, China.
出版信息
Front Endocrinol (Lausanne). 2021 Apr 23;12:641623. doi: 10.3389/fendo.2021.641623. eCollection 2021.
OBJECTIVE
To explore the live birth rate and neonatal outcome after single vitrified blastocyst transfer versus single vitrified cleavage-stage embryo transfer at different grades of embryo quality.
METHODS
A retrospective cohort study including 6077 single vitrified-thawed embryo transfer cycles was performed in the time-period from January 2013 to December 2018.
RESULTS
After controlling for potential confounding variables, there are 161% increased odds of a live birth after transfer of single good quality embryo at day 5, 152% increased odds of a live birth after transfer of single poor quality embryo at day 5, 60% increased odds of a live birth after transfer of single good quality embryo at day 6 compared with transfer of single good quality embryo at day 3. Results from the generalized estimated equation regression showed significant relationship of unadjusted birth weight with development stage of embryo and embryo quality (good quality embryo on day 5 vs. Good quality embryo on day 3:β=108.55, SE=34.89, P=0.002; good quality embryo on day 6 vs. Good quality embryo on day 3:β=68.80, SE=33.75, P=0.041). However, no significant differences were seen in birth weight between transfer single poor quality embryo on day 5, 6 and transfer single good quality embryo on day 3.
CONCLUSION
A significant increase in live birth rate and birth weight after transfer of single good quality embryo on day 5 and day 6 compared with transfer of single good quality embryo on day 3 in the vitrified embryo transfer cycles.
目的
探讨不同胚胎质量等级的单个玻璃化冷冻囊胚移植与单个玻璃化冷冻卵裂期胚胎移植的活产率和新生儿结局。
方法
本研究为回顾性队列研究，纳入了 2013 年 1 月至 2018 年 12 月期间的 6077 个单个玻璃化解冻胚胎移植周期。
结果
在控制潜在混杂因素后，与第 3 天移植优质胚胎相比，第 5 天移植单个优质胚胎的活产率增加 161%，第 5 天移植单个质量差的胚胎的活产率增加 152%，第 6 天移植单个优质胚胎的活产率增加 60%。广义估计方程回归结果显示，未校正的出生体重与胚胎发育阶段和胚胎质量呈显著相关（第 5 天的优质胚胎与第 3 天的优质胚胎：β=108.55，SE=34.89，P=0.002；第 6 天的优质胚胎与第 3 天的优质胚胎：β=68.80，SE=33.75，P=0.041）。然而，第 5 天、第 6 天移植单个质量差的胚胎与第 3 天移植单个优质胚胎的出生体重之间无显著差异。
结论
在玻璃化胚胎移植周期中，与第 3 天移植单个优质胚胎相比，第 5 天和第 6 天移植单个优质胚胎的活产率和出生体重显著增加。
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