康柏西普联合全视网膜光凝与单纯全视网膜光凝治疗糖尿病视网膜病变的疗效比较：一项Meta分析
The Effectiveness of Conbercept Combined with Panretinal Photocoagulation vs. Panretinal Photocoagulation in the Treatment of Diabetic Retinopathy: A Meta-Analysis.
作者信息
Huang Chao, Ji Haiqing, Han Xuguang
机构信息
Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Outpatient Department, Weifang Eye Hospital, Weifang, Shandong, China.
出版信息
J Ophthalmol. 2021 May 8;2021:5591719. doi: 10.1155/2021/5591719. eCollection 2021.
OBJECTIVE
This meta-analysis aimed to compare the effect and safety of conbercept with panretinal photocoagulation (PRP) vs. PRP in the treatment of diabetic retinopathy (DR).
METHODS
Relevant studies were identified through systemic searches of PubMed, EMBASE, China National Knowledge Infrastructure, and Wanfang database up to December 2020. The results of conbercept and PRP in patients with DR were analyzed, including overall effectiveness, best corrected visual acuity, central macular thickness, and complications.
RESULTS
12 articles involving 1244 patients with DR were identified for this meta-analysis. The results of the meta-analysis showed that conbercept combined with PRP significantly increased the level of overall effectiveness and significantly reduced the central thickness of macula and the incidence of complications compared with the control group.
CONCLUSIONS
Conbercept with PRP tended to be more effective than PRP alone in terms of functional outcomes for treating DR.
目的
本荟萃分析旨在比较康柏西普联合全视网膜光凝（PRP）与单纯PRP治疗糖尿病性视网膜病变（DR）的疗效和安全性。
方法
通过系统检索截至2020年12月的PubMed、EMBASE、中国知网和万方数据库来确定相关研究。分析了康柏西普和PRP治疗DR患者的结果，包括总体有效性、最佳矫正视力、黄斑中心厚度和并发症。
结果
本荟萃分析纳入了12篇涉及1244例DR患者的文章。荟萃分析结果显示，与对照组相比，康柏西普联合PRP显著提高了总体有效性水平，显著降低了黄斑中心厚度和并发症发生率。
结论
在治疗DR的功能结局方面，康柏西普联合PRP似乎比单纯PRP更有效。
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